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Dopamine D1 Receptor Within Basolateral Amygdala Is Involved in Propofol Relapse Behavior Induced by Cues

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Abstract

Propofol has been proven to be potentially abused by humans and laboratory animals; however, studies that have examined propofol relapse behavior are limited, and its underlying mechanism remains unclear. In this study, we examined whether basolateral amygdala-specific or systematic administration of the dopamine receptor antagonist alters cue-induced propofol-seeking behaviors in a rat model. Male Sprague–Dawley rats first received 14 days of propofol self-administration training, where active nose poke resulted in the delivery of propofol infusion paired with a tone and light cues. After 1–30 days of forced abstinence, the cue-induced propofol-seeking behaviors were tested in the operant chamber. We demonstrated, for the first time, after a few days of withdrawal from intravenous bolus administration of propofol, propofol-related cues could induce robust reinstatement of drug-seeking behavior. Systematic administration of dopamine D1 receptor antagonist (SCH-23390) or dopamine D2 receptor antagonist (spiperone) inhibited propofol relapse behavior induced by drug-related cues. Furthermore, we show that microinfusion of SCH-23390 into basolateral amygdala dose-dependently attenuated cue-induced propofol drug-seeking behavior, whereas infusion of spiperone had no effect on the propofol relapse behavior. Our results reveal the involvement of dopamine receptors within the basolateral amygdala in the cue-induced propofol relapse behavior in rats.

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Acknowledgements

This work was supported in part by the National Nature Science Foundation of China (81771431) and Science & Technology Foundation of Wenzhou (2017Y0643).

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Authors and Affiliations

  1. Department of Anesthesiology, Perioperative and Pain Medicine, The Second Affiliated Hospital and Yuying Children’s Hospital of Wenzhou Medical University, No.109, Xue-yuan Road(West), Lu-cheng District, Wenzhou, 325027, China

    Sicong Wang, Suhao Bao, Benfu Wang, Binbin Wu, Ying Su & Qingquan Lian

  2. Department of Anesthesiology, Suzhou Municipal Hospital, Suzhou, 234000, China

    Xin Wang

  3. Department of Anesthesiology, Sir Run Run Shaw Hospital of Zhejiang University School of Medicine, Hangzhou, 310016, China

    Wenxuan Lin

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  1. Sicong Wang
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Correspondence to Qingquan Lian.

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Wang, S., Wang, X., Lin, W. et al. Dopamine D1 Receptor Within Basolateral Amygdala Is Involved in Propofol Relapse Behavior Induced by Cues. Neurochem Res 43, 2393–2403 (2018). https://doi.org/10.1007/s11064-018-2667-8

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