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Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway

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Abstract

Clinical studies have demonstrated that decreased adiponectin is associated with the development of Type 2 diabetes mellitus (T2DM) and Alzheimer’s disease (AD). We focused on determining the neuroprotective effect offered by adiponectin against streptozotocin-induced brain damage in ICV-STZ rat model. We found that adiponectin supplements significantly restored the cognitive deficits in ICV-STZ rat model including shorter escape latency, more crossing times and increased time spent in the target quadrant. Adiponectin supplements also increased number of dendritic branches and mushroom percentage. In addition, adiponectin supplements attenuated tau hyperphosphorylation at multiple AD-related sites through activation of protein Ser9-phosphorylated glycogen synthase kinase-3β (Ser9-GSK-3β) with increased the Akt and PI3K activity. Our data suggest that adiponectin supplements have neuroprotective effects on the ICV-STZ rat model, which may be mediated by the activation of the PI3K/Akt/GSK-3β signaling pathway.

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Acknowledgements

This project was supported by the Natural Science Foundation of Hubei Province of China (2014CFB223) and the Wuhan Training Program Foundation for Youth Medical Talents.

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  1. Zhi-Peng Xu and Guo-Sheng Gan have contributed equally to this work.

Authors and Affiliations

  1. Department of Neurology, Zhongnan Hospital, Wuhan University, Wuhan, 430071, China

    Zhi-Peng Xu, Yu-Min Liu, Jin-Song Xiao, Han-Xing Liu, Bin Mei & Jun-Jian Zhang

  2. Department of Anesthesiology, Wuhan General Hospital of PLA, Wuhan, 430070, China

    Zhi-Peng Xu & Guo-Sheng Gan

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  1. Zhi-Peng Xu
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Correspondence to Jun-Jian Zhang.

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Xu, ZP., Gan, GS., Liu, YM. et al. Adiponectin Attenuates Streptozotocin-Induced Tau Hyperphosphorylation and Cognitive Deficits by Rescuing PI3K/Akt/GSK-3β Pathway. Neurochem Res 43, 316–323 (2018). https://doi.org/10.1007/s11064-017-2426-2

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  • DOI: https://doi.org/10.1007/s11064-017-2426-2

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