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Mitophagy in Ischaemia/Reperfusion Induced Cerebral Injury

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Abstract

Mitochondrial autophagy (Mitophagy), the specific autophagic elimination of mitochondria, has been related with several forms of degenerative disease and mitochondrial dysfunction. It is involved in multiple cellular processes. In addition to one of its established key roles in the maintenance of normal cellular phenotype and function, there is growing interest in the concept that targeted modulation of mitophagy may reduce cerebral ischaemia/reperfusion injury. Induction of mitophagy results in selective clearance of damaged mitochondria in cells. In response to stress such as ischaemia/reperfusion, prosurvival and prodeath pathways are concomitantly activated in neuronal cells.

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Acknowledgments

This work was supported by grants from the project of National Natural Science Foundation of China (No. 31171014 and No. 30970869), the project of Science and Technology Commission of Shanghai Municipality (No. 09DZ1950400) and Board of Health of Shanghai, China (No. 2008086), the youth projects of National Natural Science Foundation of China (No. 31100783) and Youth Key Project in Shanghai college of Medicine of Fudan University (No. 09-L37).

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Authors and Affiliations

  1. Department of Neurology, Shanghai Pudong New Area Zhoupu Hospital, Shanghai, People’s Republic of China

    Kangyong Liu, Zhaohua Gu & Nan Shi

  2. Department of Neurology, Affiliated Sixth People’s Hospital of Shanghai Jiaotong University, Yishan Road, Xuhui District, Shanghai, 200233, People’s Republic of China

    Kangyong Liu, Yinyi Sun, Ting Zhang & Xiaojiang Sun

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  1. Kangyong Liu
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  2. Yinyi Sun
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  3. Zhaohua Gu
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  4. Nan Shi
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Correspondence to Xiaojiang Sun.

Additional information

Kangyong Liu and Yinyi Sun contributed to this work equally.

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Liu, K., Sun, Y., Gu, Z. et al. Mitophagy in Ischaemia/Reperfusion Induced Cerebral Injury. Neurochem Res 38, 1295–1300 (2013). https://doi.org/10.1007/s11064-013-1033-0

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  • DOI: https://doi.org/10.1007/s11064-013-1033-0

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