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Differential Effects of Treadmill Exercise in Early and Chronic Diabetic Stages on Parvalbumin Immunoreactivity in the Hippocampus of a Rat Model of Type 2 Diabetes

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Abstract

In the present study, we investigated the effects of treadmill exercise in early and chronic diabetic stages on parvalbumin (PV) immunoreactivity in the subgranular zone of the dentate gyrus of Zucker diabetic fatty (ZDF) and its lean control rats (ZLC). To investigate the effects, ZLC and ZDF rats at 6 or 23 weeks of age were put on a treadmill with or without running for 1 h/day/5 consecutive days at 16–22 m/min for 5 weeks or 12–16 m/min for 7 weeks, respectively. Physical exercise in pre-diabetic rats prevented onset of diabetes, while exercise in rats at chronic diabetic stage significantly reduced blood glucose levels. In addition, physical exercise in the pre-diabetic rats significantly increased PV immunoreactive fibers in the strata oriens and radiatum of the CA1-3 region and in the polymorphic and molecular layers of the dentate gyrus compared to that in sedentary controls. However, in rats at chronic stages, PV immunoreactivity was slightly increased in the CA1-3 region as well as in the dentate gyrus compared to that in the sedentary controls. These results suggest that physical exercise has differential effects on blood glucose levels and PV immunoreactivity according to diabetic stages. Early exercise improves diabetic phenotype and PV immunoreactive fibers in the rat hippocampus.

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Acknowledgments

This work was supported by the National Research Foundation of Korea Grant funded by the Korean Government (MEST), Republic of Korea (2010-0007712).

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Authors and Affiliations

  1. Department of Anatomy and Cell Biology College of Veterinary Medicine, Research Institute for Veterinary Science, Seoul National University, Seoul, 151-742, South Korea

    In Koo Hwang, Sun Shin Yi, Yeo Sung Yoon & Je Kyung Seong

  2. Department of Biomedical Sciences, College of Health Sciences, Marquette University, Milwaukee, WI, 53233, USA

    Sun Shin Yi

  3. Department of Oral Anatomy, College of Dentistry, Gangneung-Wonju National University, Gangneung, 210-702, South Korea

    Ki-Yeon Yoo

  4. Division of Analytical Bio-imaging, Chuncheon Center, Korea Basic Science Institute, Chuncheon, 200-701, South Korea

    Ok Kyu Park

  5. Department of Neurobiology, School of Medicine, Kangwon National University, Chuncheon, 200-701, South Korea

    Bingchun Yan & Moo-Ho Won

  6. Institute of Sports Science, Seoul National University, Seoul, 151-742, South Korea

    Wook Song

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  1. In Koo Hwang
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  2. Sun Shin Yi
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Correspondence to Yeo Sung Yoon or Je Kyung Seong.

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In Koo Hwang and Sun Shin Yi contributed equally to this article.

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Hwang, I.K., Yi, S.S., Yoo, KY. et al. Differential Effects of Treadmill Exercise in Early and Chronic Diabetic Stages on Parvalbumin Immunoreactivity in the Hippocampus of a Rat Model of Type 2 Diabetes. Neurochem Res 36, 1526–1532 (2011). https://doi.org/10.1007/s11064-011-0480-8

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