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The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease

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Abstract

We examined oxidative stress markers of 31 patients suffering from ALS, 24 patients suffering from PD and 30 healthy subjects were included. We determined the plasma levels of lipid peroxidation (malondialdehyde, MDA), of protein oxidative lesions (plasma glutathione, carbonyls and thiols) and the activity of antioxidant enzymes i.e. erythrocyte Cu,Zn-Superoxide dismutase (SOD), Glutathione peroxidase (GSH-Px) and catalase. MDA and thiols were significantly different in both neurodegenerative diseases versus control population. A trend for an enhancement of oxidized glutathione was noted in ALS patients. Univariate analysis showed that SOD activity was significantly decreased in ALS and GSH-Px activity was decreased in PD. After adjusting for demographic parameters and enzyme cofactors, we could emphasize a compensatory increase of SOD activity in PD. Different antioxidant systems were not involved in the same way in ALS and PD, suggesting that oxidative stress may be a cause rather than a consequence of the neuronal death.

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Abbreviations

ALS:

Amyotrophic lateral sclerosis

EDTA:

Ethylenediaminetetraacetic acid

GSH-Px:

Glutathione peroxidase

MDA:

Malondialdehyde

MOPS:

3-N-morpholinopropaneslfonic acid

PD:

Parkinson’s disease

SOD:

Cu,Zn-Superoxide dismutase

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Authors and Affiliations

  1. Neurology Department, Hôpital A. Michallon, 38043, Grenoble Cedex 9, France

    Athan Baillet & Gérard Besson

  2. Biology Department, Hôpital A Michallon, 38043, Grenoble Cedex 9, France

    Vanessa Chanteperdrix & Catherine Garrel

  3. Laboratory of Enzymology/DBPC, CHU Hôpital Michallon, 38043, Grenoble Cedex 9, France

    Candice Trocmé

  4. Medical Information Unit, A. Michallon, 38043, Grenoble Cedex 9, France

    Pierre Casez

  5. Grenoble University, Hôpital A. Michallon, 38043, Grenoble Cedex 9, France

    Athan Baillet

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  1. Athan Baillet
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  2. Vanessa Chanteperdrix
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  3. Candice Trocmé
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  4. Pierre Casez
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  5. Catherine Garrel
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Correspondence to Athan Baillet.

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Baillet, A., Chanteperdrix, V., Trocmé, C. et al. The Role of Oxidative Stress in Amyotrophic Lateral Sclerosis and Parkinson’s Disease. Neurochem Res 35, 1530–1537 (2010). https://doi.org/10.1007/s11064-010-0212-5

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  • DOI: https://doi.org/10.1007/s11064-010-0212-5

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