Neurochemical Research

, Volume 33, Issue 3, pp 533–538 | Cite as

DARPP-32 and NCS-1 Expression is not Altered in Brains of Rats Treated with Typical or Atypical Antipsychotics

  • Bruno R. Souza
  • Bernardo S. Motta
  • Daniela V. F. Rosa
  • Karen C. L. Torres
  • Adalberto A. Castro
  • Clarissa M. Comim
  • André M. Sampaio
  • Fabrício F. Lima
  • Andreas Jeromin
  • João Quevedo
  • Marco A. Romano-SilvaEmail author
Original Paper


Dopamine-mediated neurotransmission imbalances are associated with several psychiatry illnesses, such as schizophrenia. Recently it was demonstrated that two proteins involved in dopamine signaling are altered in prefrontal cortex (PFC) of schizophrenic patients. DARPP-32 is a key downstream effector of intracellular signaling pathway and is downregulated in PFC of schizophrenic subjects. NCS-1 is a neuronal calcium sensor that can inhibit dopamine receptor D2 internalization and is upregulated in PFC of schizophrenic subjects. It is well known that dopamine D2 receptor is the main target of antipsychotic. Therefore, our purpose was to study if chronic treatment with typical or atypical antipsychotics induced alterations in DARPP-32 and NCS-1 expression in five brain regions: prefrontal cortex, hippocampus, striatum, cortex and cerebellum. We did not find any changes in DARPP-32 and NCS-1 protein expression in any brain region investigated.


DARPP-32 NCS-1 Antipsychotic Schizophrenia 



This research was supported by grants from Eli Lilly do Brazil, UNESC and CNPq.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Bruno R. Souza
    • 1
  • Bernardo S. Motta
    • 1
  • Daniela V. F. Rosa
    • 1
  • Karen C. L. Torres
    • 1
  • Adalberto A. Castro
    • 2
  • Clarissa M. Comim
    • 2
  • André M. Sampaio
    • 1
  • Fabrício F. Lima
    • 1
  • Andreas Jeromin
    • 3
  • João Quevedo
    • 2
  • Marco A. Romano-Silva
    • 1
    • 4
    Email author
  1. 1.Laboratório de Neurociências, Departamento de Saúde Mental, Faculdade de MedicinaUniversidade Federal de Minas GeraisBelo HorizonteBrazil
  2. 2.Laboratorio de Neurociências, Programa de Pós-Graduação em Ciências da SaúdeUniversidade do Extremo Sul CatarinenseCriciumaBrazil
  3. 3.Center for Learning and MemoryUniversity of Texas at AustinAustinUSA
  4. 4.Departamento de Farmacologia – ICBUniversidade Federal de Minas GeraisBelo HorizonteBrazil

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