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Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin

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Abstract

Various studies reported on the neuroprotective effects of natural products, particularly polyphenols, widely present in food and beverages. For example, we have shown that resveratrol, a polyphenol contained present in red wine and other foods, activates the phosphorylation of protein kinase C (PKC), this effect being involved in its neuroprotective action against Aß-induced toxicity. Moreover, tea-derived catechin gallate esters inhibit the formation Aß oligomers/fibrils, suggesting that this action likely contributes to their neuroprotective effects. Interestingly, the effects of polyphenols may be attributable, at least in part, to the presence of specific binding sites. Autoradiographic studies revealed that these binding sites are particularly enriched in choroids plexus in the rat brain. Interestingly, the choroid plexus secretes transthyretin, a protein that has been shown to prevent Aβ aggregation and that may be critical to the maintenance of normal learning capacities in aging. Taken together, these data suggest that polyphenols target multiple enzymes/proteins leading to their neuroprotective actions.

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Acknowldgments

This work was supported by grants from the Canadian Institutes of Health Research (CIHR) to R.Q. and a student scholarship from CIHR to J.B.

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Authors and Affiliations

  1. Department of Psychiatry, Douglas Hospital Research Centre, McGill University, 6875 LaSalle Boulevard, Verdun, Montreal, QC, Canada, H4H 1R3

    Stéphane Bastianetto, Jonathan Brouillette & Rémi Quirion

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  1. Stéphane Bastianetto
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  2. Jonathan Brouillette
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  3. Rémi Quirion
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Correspondence to Rémi Quirion.

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Special issue dedicated to Dr. Moussa Youdim.

Stéphane Bastianetto, Jonathan Brouillette contributed equally to the manuscript.

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Bastianetto, S., Brouillette, J. & Quirion, R. Neuroprotective Effects of Natural Products: Interaction with Intracellular Kinases, Amyloid Peptides and a Possible Role for Transthyretin. Neurochem Res 32, 1720–1725 (2007). https://doi.org/10.1007/s11064-007-9333-x

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