Abstract
In mice kept on a diet with no vitamin B1, the total content of thiamine in the brain decreased, and muscle contractions evoked by stimulation of the nerve in phrenico-diaphragmatic preparations obtained from such animals became weaker. The measurements were performed in Krebs solution with a decreased content of Ca2+ and increased concentration of Mg2+; values of the developed force were normalized with respect to those in normal Krebs solution. Thus, B1 hypovitaminosis results in a decrease in the efficacy of neuromuscular synaptic transmission. Some neurological symptoms typical of a deficiency of vitamin B1 in the organism can be related to this effect.
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Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 416–418, July–October, 2007.
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Romanenko, A.V., Shepelev, S.E. Effect of B1 hypovitaminosis on the efficacy of neuromuscular transmission in the murine diaphragm. Neurophysiology 39, 366–368 (2007). https://doi.org/10.1007/s11062-007-0059-9
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DOI: https://doi.org/10.1007/s11062-007-0059-9