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Changes of lipidemia after one month of creatine supplementation

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Abstract

It was proved in two independent experimental studies with the same group of 11 young sportsmen that creatine (CR) given as food supplement interfered with the metabolism of one- and two-carbon units. CR, given in one dose of 5 g daily during one month, induced reciprocal changes of muscle mass and body fat. These changes were characteristic of each of the four proband groups, into which the probands were divided on basis of the increased or decreased level of CR in urine, and the increased or decreased levels of folates and vitamin B12 in blood. The comparison of results of short- and long-term CR supplementations showed that individual deviations found within the rank of each group are characteristic for each person under study. The changes of the level of thiodiglycolic acid in urine proved to be good markers for deviations from homeostasis.

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References

  1. Olsen S, Aagaard P, Kadi F, Tufekovic G, Verney J, Olesen JL, Suetta C, Kjaer M (2006) J Physiol Lond 573:525

    Article  CAS  Google Scholar 

  2. Navratil T, Kohlikova E, Petr M, Pelclova D, Heyrovsky M, Pristoupilova K (2010) Physiol Res 59:431

    CAS  Google Scholar 

  3. Persky AM, Brazeau GA (2001) Pharmacol Rev 53:161

    CAS  Google Scholar 

  4. Wyss M, Kaddurah-Daouk R (2000) Physiol Rev 80:1107

    CAS  Google Scholar 

  5. Finkelstein JD (1990) J Nutr Biochem 1:228

    Article  CAS  Google Scholar 

  6. Finkelstein JD, Martin JJ, Harris BJ (1988) J Biol Chem 263:11750

    CAS  Google Scholar 

  7. Petr M, Navratil T, Heyrovsky M, Kohlikova E (2011) Curr Org Chem 15:3029

    Article  CAS  Google Scholar 

  8. Navratil T, Kohlikova E, Petr M, Pristoupilova K (2010) Effect of creatine applied as food supplement on human metabolism. In: Haugen S, Meijer S (eds) Handbook of nutritional biochemistry: genomics, metabolomics and food supply, 1st edn. Nova Science Publishers, Hauppauge, p 317

    Google Scholar 

  9. Navratil T, Kohlikova E, Petr M, Heyrovsky M, Pelclova D, Pristoupilova K, Pristoupil TI, Senholdova Z (2009) Food Chem 112:500

    Article  CAS  Google Scholar 

  10. Navratil T (2011) Study of human metabolic processes leading to the formation of thiodiglycolic acid. Habilitation Thesis, First Faculty of Medicine, Charles University in Prague, Prague

  11. Petr M (2007) Metabolic pathways leading to excretion of thiodiglycolic acid into urine affected by creatine supplementation. PhD Thesis, Charles University, Prague

  12. Dubey SN, Beweja RK, Puri DM (1983) Indian J Chem Sect A Inorg Bio-inorg Phys Theor Anal Chem 22:450

    Google Scholar 

  13. Zagalak B, Friedrich W (1979) Vitamin B12, 1st edn. deGruyter, Berlin

    Google Scholar 

  14. Murray RK, Bender D, Botham KM, Kennelly PJ, Rodwell VW, Weil PA (2012) Harper’s illustrated biochemistry. McGraw-Hill Lange, Columbus

    Google Scholar 

  15. Steventon GB (1999) Drug Metab Dispos 27:1092

    CAS  Google Scholar 

  16. Pristoupilova K, Pristoupil TI, Navratil T, Heyrovsky M, Senholdova Z, Pelclova D (2005) Anal Lett 38:613

    Article  CAS  Google Scholar 

  17. Navratil T, Petr M, Senholdova Z, Pristoupilova K, Pristoupil TI, Heyrovsky M, Pelclova D, Kohlikova E (2007) Physiol Res 56:113

    CAS  Google Scholar 

  18. Petr M, Steffl M, Kohlikova E (2013) Physiol Res 62:721

    CAS  Google Scholar 

  19. Dlaskova Z, Dvorakova L, Navratil T, Basova P (2001) Chem Listy 95:184

    CAS  Google Scholar 

  20. Dlaskova Z, Navratil T, Heyrovsky M, Pelclova D, Novotny L (2003) Anal Bioanal Chem 375:164

    CAS  Google Scholar 

  21. Navratil T, Senholdova-Dlaskova Z, Heyrovsky M, Pristoupilova K, Pristoupil TI, Pelclova D (2004) Anal Lett 37:1093

    Article  CAS  Google Scholar 

  22. Gal M, Hives J, Sokolova R, Hromadova M, Kolivoska V, Pospisil L (2009) Collect Czech Chem Commun 74:1571

    Article  CAS  Google Scholar 

  23. Sokolova R, Degano I, Hromadova M, Bulickova J, Gal M, Valasek M (2010) Collect Czech Chem Commun 75:1097

    Article  CAS  Google Scholar 

  24. Gal M, Hromadova M, Pospisil L, Hives J, Sokolova R, Kolivoska V, Bulickova J (2010) Bioelectrochemistry 78:118

    Article  CAS  Google Scholar 

  25. Sokolova R, Degano I, Ramesova S, Bulickova J, Hromadova M, Gal M, Fiedler J, Valasek M (2011) Electrochim Acta 56:7421

    Article  CAS  Google Scholar 

  26. Hromadova M, Kolivoska V, Sokolova R, Gal M, Pospisil L, Valasek M (2010) Langmuir 26:17232

    Article  CAS  Google Scholar 

  27. Jaklova Dytrtova J, Sestakova I, Jakl M, Navratil T (2009) Electroanalysis 21:573

    Article  Google Scholar 

  28. Skopalova J, Navratil T (2007) Chem Anal Warsaw 52:961

    CAS  Google Scholar 

  29. Matelkova K, Ossberger K, Hudak J, Vatral J, Boca R, Linert W (2013) Monatsh Chem 144:937

    Article  CAS  Google Scholar 

  30. Moradi S, Ajloo D, Lashkarbolouki T, Alizadeh R, Saboury AA (2013) Monatsh Chem 144:1499

    Article  CAS  Google Scholar 

  31. Raman N, Sobha S, Selvaganapathy M (2012) Monatsh Chem 143:1487

    Article  CAS  Google Scholar 

  32. Sakthivel A, Raman N, Mitu L (2013) Monatsh Chem 144:605

    Article  CAS  Google Scholar 

  33. Chylkova J, Fadrna R (2004) Chem Listy 98:260

    CAS  Google Scholar 

  34. Samcova E, Kvasnicova V, Urban J, Jelinek I, Coufal P (1999) J Chromatogr A 847:135

    Article  CAS  Google Scholar 

  35. Senholdova-Dlaskova Z (2002) Polarographic/voltammetric determination of thiodiglycolic acid as the indicator of exposure to vinylchloride. Ph.D. Thesis, University Pardubice, Pardubice

  36. Steventon G, Waring R, Sturman S, Heafield M, Williams A (1999) Med Sci Res 27:119

    CAS  Google Scholar 

  37. Ermakova IT, Starovoitov II, Tikhonova EB, Slepen’kin AV, Kashparov KI, Boronin AM (2002) Process Biochem 38:31

    Article  CAS  Google Scholar 

  38. Lee TS, Chan SH, Weigand WA, Bentley WE (2000) Biotechnol Prog 16:363

    Article  CAS  Google Scholar 

  39. Bandzuchova L, Selesovska R, Navratil T, Chylkova J (2011) Electrochim Acta 56:2411

    Article  CAS  Google Scholar 

  40. Selesovska R, Bandzuchova L, Navratil T, Chylkova J (2012) Electrochim Acta 60:375

    Article  CAS  Google Scholar 

  41. Bandzuchova L, Selesovska R, Navratil T, Chylkova J (2012) Electroanalysis 25:213

    Article  Google Scholar 

  42. Novotny L, Navratil T (1998) Electroanalysis 10:557

    Article  CAS  Google Scholar 

  43. Barek J, Dodova E, Navratil T, Yosypchuk B, Novotny L, Zima J (2003) Electroanalysis 15:1778

    Article  CAS  Google Scholar 

  44. Barek J, Fischer J, Navratil T, Peckova K, Yosypchuk B (2006) Sensors Basel 6:445

    Article  CAS  Google Scholar 

  45. Cizkova P, Navratil T, Sestakova I, Yosypchuk B (2007) Electroanalysis 19:161

    Article  CAS  Google Scholar 

  46. Fischer J, Barek J, Yosypchuk B, Navratil T (2006) Electroanalysis 18:127

    Article  CAS  Google Scholar 

  47. Bandzuchova L, Selesovska R, Navratil T, Chylkova J, Novotny L (2012) Electrochim Acta 75:316

    Article  CAS  Google Scholar 

  48. Bandzuchova L, Selesovska R, Navratil T, Chylkova J (2013) Electrochim Acta 113:1

    Article  CAS  Google Scholar 

  49. Vyskocil V, Navratil T, Polaskova P, Barek J (2010) Electroanalysis 22:2034

    Article  CAS  Google Scholar 

  50. Selesovska-Fadrna R, Navratil T, Vlcek M (2007) Chem Anal Warsaw 52:911

    CAS  Google Scholar 

  51. Cabalkova D, Barek J, Fischer J, Navratil T, Peckova K, Yosypchuk B (2009) Chem Listy 103:236

    CAS  Google Scholar 

  52. Barek J, Cabalkova D, Fischer J, Navratil T, Peckova K, Yosypchuk B (2011) Environ Chem Lett 9:83

    Article  CAS  Google Scholar 

  53. Selesovska R, Bandzuchova L, Navratil T (2011) Electroanalysis 23:177

    Article  CAS  Google Scholar 

  54. Barek J, Fischer J, Navratil T, Peckova K, Yosypchuk B, Zima J (2007) Electroanalysis 19:2003

    Article  CAS  Google Scholar 

  55. Navratil T, Kopanica M (2002) Crit Rev Anal Chem 32:153

    Article  CAS  Google Scholar 

  56. Navratil T, Kopanica M (2002) Chem Listy 96:111

    CAS  Google Scholar 

  57. Navratil T (2011) Curr Org Chem 15:2996

    Article  CAS  Google Scholar 

  58. Navratil T, Senholdova Z, Shanmugam K, Barek J (2006) Electroanalysis 18:201

    Article  CAS  Google Scholar 

  59. Navratil T, Barek J (2009) Crit Rev Anal Chem 39:131

    Article  CAS  Google Scholar 

  60. Yosypchuk B, Navratil T, Lukina AN, Peckova K, Barek J (2007) Chem Anal Warsaw 52:897

    CAS  Google Scholar 

  61. Navratil T, Barek J, Fasinova-Sebkova S (2009) Electroanalysis 21:309

    Article  CAS  Google Scholar 

  62. Dou C, Xia DY, Zhang LQ, Chen XR, Flores P, Datta A, Yuan C (2005) Clin Chem 51:1987

    Article  CAS  Google Scholar 

  63. Beckman-Coulter (2008) Access® Vitamin B12. http://www.beckman.com/. Accessed 3 Sep 2014

  64. Kraml J (1999) Instruction for practical lessons in medicinal biochemistry (in Czech). Karolinum, Prague

    Google Scholar 

  65. Bardodej Z, David A, Sedivec V, Skramovsky S, Teisinger J (1989) Exposure tests in industrial toxicology (in Czech). Avicenum, Prague

    Google Scholar 

  66. Slavik K (1962) The metabolism and coenzyme forms of folic acid. World review of nutrition and dietetics. Pitman Medical Publishing, London

    Google Scholar 

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Acknowledgments

T. Navrátil thanks for the support of the Czech Science Foundation (project GA ČR No. P208/12/1645). M. Petr and E. Kohlíková thank for the support of the project PRVOUK P.38. The authors express their gratitude to Dr. Kamila Přistoupilová, without whose help this article could not have been written. They thank Dr. Michael Heyrovsky for his help and language correction.

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Authors and Affiliations

  1. J. Heyrovský Institute of Physical Chemistry of AS CR, v.v.i., Dolejškova 3, 182 23, Prague 8, Czech Republic

    Tomáš Navrátil

  2. Institute of Medical Biochemistry and Laboratory Medicine, First Faculty of Medicine, Charles University in Prague and General University Hospital in Prague, Prague, Czech Republic

    Tomáš Navrátil

  3. Department of Physiology and Biochemistry, Faculty of Physical Education and Sport, Charles University in Prague, José Martího, 162 52, Prague 6, Czech Republic

    Miroslav Petr & Eva Kohlíková

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  1. Tomáš Navrátil
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Correspondence to Tomáš Navrátil.

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Navrátil, T., Petr, M. & Kohlíková, E. Changes of lipidemia after one month of creatine supplementation. Monatsh Chem 146, 771–780 (2015). https://doi.org/10.1007/s00706-014-1336-0

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  • DOI: https://doi.org/10.1007/s00706-014-1336-0

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