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Effects of haloperidol and clotrimazole on synaptic transmission in and contractile activity of smooth muscles of the guinea-pig intestine

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Abstract

In muscle strips of the guinea-pig large intestine, haloperidol and clotrimazole increased spontaneous electrical and contractile activities and decreased ATP-evoked hyperpolarization of smooth-muscle cells and the amplitude of inhibitory synaptic potentials. The pattern of effects of haloperidol on hyperpolarization induced by intramural stimulation of muscle strips was preserved under conditions of pre-incubation of the preparations in Krebs solutions containing pyridoxal-5′-phosphate, Nω-nitro-L-arginine, or apamin, as well as both apamin and tetraethylammonium.

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Authors and Affiliations

  1. Ministry of Public Health of Ukraine, Bogomolets National Medical University, Kyiv, Ukraine

    A. V. Romanenko & M. M. Grusha

Authors
  1. A. V. Romanenko
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  2. M. M. Grusha
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Correspondence to M. M. Grusha.

Additional information

Neirofiziologiya/Neurophysiology, Vol. 39, Nos. 4/5, pp. 412–415, July–October, 2007.

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Romanenko, A.V., Grusha, M.M. Effects of haloperidol and clotrimazole on synaptic transmission in and contractile activity of smooth muscles of the guinea-pig intestine. Neurophysiology 39, 362–365 (2007). https://doi.org/10.1007/s11062-007-0058-x

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  • DOI: https://doi.org/10.1007/s11062-007-0058-x

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