Skip to main content
SpringerLink
Log in

Superficial meningioma with bone involvement: surgical strategies and clinical outcomes

  • Research
  • Published:
Journal of Neuro-Oncology Aims and scope Submit manuscript

Abstract

Introduction

Meningiomas with bone involvement account for 4.5–17% of all intracranial meningiomas. Little is known about whether these meningiomas (WHO grade I) behave differently than meningiomas without bone involvement. We sought to study the relatively uncommon imaging manifestations of meningioma and to evaluate their clinical significance.

Methods

A single-institution retrospective cohort study of surgically treated superficial meningioma patients between 2011 and 2022 was conducted. Age, sex, preoperative imaging, operative data, and surgical outcomes were reviewed. Imaging variables and outcomes were reported for patients with bone-invading meningiomas and compared with those with nonbone-invading meningiomas. Univariate analyses were also conducted.

Results

Of 577 total superficial meningiomas treated surgically, 47 (8.1%) exhibited bone invasion. Most bone-invading meningiomas were parasagittal (n = 29, 61.7%). A total of 12.7% (n = 6) of patients with bone-invading meningioma had recurrence, whereas 9.1% (n = 48) of patients with non-bone-invading meningioma had recurrence (p = 0.426). No significant difference in the median time to recurrence was observed between patients with bone-invading meningiomas and patients with nonbone-invading meningiomas (69.8 months, Q1:53.1; Q3:81.4 months vs. 69.7 months, Q1:47.5; Q3:96.7; p = 0.638).

Conclusions

Superficial meningioma with bone involvement had similar outcomes compared to those of superficial meningioma without bone involvement. Hyperostosis in meningioma (WHO grade I) may not be a surrogate for aggressive meningioma behavior.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3

Similar content being viewed by others

Data availability

No datasets were generated or analysed during the current study.

References

  1. Ottenhausen M, Rumalla K, Younus I, Minkowitz S, Tsiouris AJ, Schwartz TH (2018) Predictors of postoperative motor function in rolandic meningiomas. J Neurosurg 130:1283–1288. https://doi.org/10.3171/2017.12.JNS172423

    Article  PubMed  Google Scholar 

  2. Marbacher S, Coluccia D, Fathi AR, Andereggen L, Beck J, Fandino J (2013) Intraoperative patient-specific reconstruction of partial bone flap defects after convexity meningioma resection. World Neurosurg 79:124–130. https://doi.org/10.1016/j.wneu.2011.05.057

    Article  PubMed  Google Scholar 

  3. Jin L, Youngblood MW, Gupte TP et al (2021) Type of bony involvement predicts genomic subgroup in sphenoid wing meningiomas. J Neurooncol 154:237–246. https://doi.org/10.1007/s11060-021-03819-2

    Article  CAS  PubMed  Google Scholar 

  4. Kalasauskas D, Tanyildizi Y, Renovanz M, Brockmann MA, Sommer CJ, Ringel F, Keric N (2021) Evaluation of resection margin after image-guided dural tail resection in Convexity meningiomas. J Clin Med 10:1177. https://doi.org/10.3390/jcm10061177

    Article  PubMed  PubMed Central  Google Scholar 

  5. Fathalla H, Tawab MGA, El-Fiki A (2020) Extent of gyperostotic bone resection in convexity meningioma to achieve pathologically free margins. J Korean Neurosurg Soc 63:821–826. https://doi.org/10.3340/jkns.2020.0020

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Goyal N, Kakkar A, Sarkar C, Agrawal D (2012) Does bony hyperostosis in intracranial meningioma signify tumor invasion? A radio-pathologic study. Neurol India 60:50–54. https://doi.org/10.4103/0028-3886.93589

    Article  PubMed  Google Scholar 

  7. Pieper DR, Al-Mefty O, Hanada Y, Buechner D (1999) Hyperostosis associated with meningioma of the cranial base: secondary changes or tumor invasion. Neurosurgery 44:742–747. https://doi.org/10.1097/00006123-199904000-00028

    Article  CAS  PubMed  Google Scholar 

  8. Gabeau-Lacet D, Aghi M, Betensky RA, Barker FG, Loeffler JS, Louis DN (2009) Bone involvement predicts poor outcome in atypical meningioma. J Neurosurg 111:464–471. https://doi.org/10.3171/2009.2.JNS08877

    Article  PubMed  PubMed Central  Google Scholar 

  9. Di Cristofori A, Del Bene M, Locatelli M, Boggio F, Ercoli G, Ferrero S, Del Gobbo A (2018) Meningioma and bone hyperostosis: expression of bone stimulating factors and review of the literature. World Neurosurg 115:e774–e781. https://doi.org/10.1016/j.wneu.2018.04.176

    Article  PubMed  Google Scholar 

  10. Kim KS, Rogers LF, Goldblatt D (1987) CT features of hyperostosing meningioma en plaque. AJR Am J Roentgenol 149:1017–1023. https://doi.org/10.2214/ajr.149.5.1017

    Article  CAS  PubMed  Google Scholar 

  11. Salehi F, Jalali S, Alkins R, Lee JI, Lwu S, Burrell K, Gentili F, Croul S, Zadeh G (2013) Proteins involved in regulating bone invasion in skull base meningiomas. Acta Neurochir (Wien) 155:421–427. https://doi.org/10.1007/s00701-012-1577-9

    Article  PubMed  Google Scholar 

  12. Sauvigny T, Giese H, Höhne J et al (2021) A multicenter cohort study of early complications after cranioplasty: results of the German Cranial Reconstruction Registry. J Neurosurg 137:591–598. https://doi.org/10.3171/2021.9.JNS211549

    Article  Google Scholar 

  13. Eaton JC, Greil ME, Nistal D, Caldwell DJ, Robinson E, Aljuboori Z, Temkin N, Bonow RH, Chesnut RM (2022) Complications associated with early cranioplasty for patients with traumatic brain injury: a 25-year single-center analysis. J Neurosurg 137:776–781. https://doi.org/10.3171/2021.11.JNS211557

    Article  Google Scholar 

  14. Traylor JI, Plitt AR, Hicks WH, Mian TM, Mickey BE, Barnett SL (2023) Evaluating risk of recurrence in patients with meningioma. J Neurosurg 138:621–628. https://doi.org/10.3171/2022.6.JNS221162

    Article  PubMed  Google Scholar 

  15. Tang AR, Chotai S, Guidry BS, Sun L, Ye F, Kelly PD, McDermott JR, Grisham CJ, Morone PJ, Thompson RC, Chambless LB (2023) Conditional recurrence-free Survival after Surgical Resection of Meningioma. Neurosurgery 93:339–347. https://doi.org/10.1227/neu.0000000000002416

    Article  PubMed  Google Scholar 

Download references

Acknowledgements

We thank Journal Experts for assisting in the preparation of this manuscript.

Author information

Author notes

  1. Authors Gang Li and Qilong Tian contributed equally to this work.

Authors and Affiliations

  1. Department of Neurosurgery, Tangdu hospital, Air Force Medical University, Xi’an, Shaanxi, China

    Gang Li, Qilong Tian, Shoujie Wang, Kailu Li, Yu Zhang & Qing Cai

Authors
  1. Gang Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Qilong Tian
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Shoujie Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Kailu Li
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Yu Zhang
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Qing Cai
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

GL: Conceptualization, Methodology. QT: Writing—original draft. SW: Visualization, Investigation. KL: Visualization, Investigation. YZ: Supervision. QC: Writing—review and editing.

Corresponding authors

Correspondence to Yu Zhang or Qing Cai.

Ethics declarations

Competing interests

The authors declare no competing interests.

Additional information

Publisher’s Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Li, G., Tian, Q., Wang, S. et al. Superficial meningioma with bone involvement: surgical strategies and clinical outcomes. J Neurooncol 168, 27–33 (2024). https://doi.org/10.1007/s11060-024-04604-7

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11060-024-04604-7

Keywords

Search

Navigation