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Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study

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Abstract

Purpose

To investigate the efficacy and safety of adjuvant radiotherapy (RT) in patients with central neurocytoma (CN).

Methods

The study included 68 patients with CN retrospectively, was further divided into surgery + RT group (31 patients) and surgery alone group (37 patients). Progression-free survival (PFS), overall survival (OS), and adverse reactions (AEs) were compared between the two groups.

Results

The median follow-up duration was 82.2 (interquartile range, 64.7-104.5) months. Patients in the surgery + RT group tended to have longer PFS than those in the surgery alone group (5-year PFS rate: 92.7% vs. 86.3%; P = 0.074). There was no significant difference in OS between the two groups (5-year OS rate: 96.8% vs. 94.3%; P = 0.639). Subgroup analysis revealed a significant improvement in PFS in patients receiving RT after surgery in patients who underwent subtotal resection (STR) (P = 0.045). In the overall population, univariate multivariate analysis revealed that gross total resection (GTR) (P = 0.002), tumor location in the unilateral ventricle (P = 0.008), and MIB-1 (Ki-67) labeling index (LI) < 5% (P = 0.009) were favorable independent prognostic factors for PFS. Whereas tumor location in the unilateral ventricle (P = 0.043) was a favorable independent prognostic factor for OS. Moreover, RT patients experienced AEs (Grade 1–2, well-tolerated).

Conclusion

Adjuvant RT in the treatment of CNs showed satisfactory safety, and postoperative RT could improve PFS in STR patients. Furthermore, GTR, tumor development in the unilateral ventricle, and MIB-1 LI < 5% were found to be favorable factors affecting the prognosis of CNs.

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Data Availability

The data presented in this study are available on request from the corresponding author. The data are not publicly available due to privacy.

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Acknowledgements

We thank the referring surgeon, radiologist and pathologists.

Funding

This study was supported by the Natural Science Foundation of Hunan Province (Grant No. 2018JJ3856).

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Authors and Affiliations

  1. Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Lei She, Dongfeng Deng, Lin Su & Chao Liu

  2. Department of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Lei She

  3. National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Lei She & Chao Liu

  4. Clinical Diagnosis and Therapy Center for Glioma of Xiangya Hospital, Central South University, Changsha, 410008, Hunan, China

    Chao Liu

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Contributions

LS, DD, LS, LC conception, design, and review. LS, DD, LS collected data. LS, LC wrote the main manuscript. LS, DD, LS, LC edited and reviewed. All authors read and approved the final version of the manuscript.

Corresponding author

Correspondence to Chao Liu.

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Conflict of interest

The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.

Ethical approval

 The study was conducted in accordance with the Declaration of Helsinki, and approved by the Ethics Committee of Xiangya Hospital of Central South University (No.202209210).

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Informed consent has been exempted.

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She, L., Deng, D., Su, L. et al. Comparison of surgery with or without adjuvant radiotherapy in treating central neurocytoma: a single-center retrospective real-world study. J Neurooncol 160, 455–462 (2022). https://doi.org/10.1007/s11060-022-04164-8

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