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Thalamic gliomas in adults: a systematic review of clinical characteristics, treatment strategies, and survival outcomes

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Abstract

Purpose

Thalamic gliomas are rare neoplasms that pose significant surgical challenges. The literature is limited to single-institution retrospective case series. We systematically review the literature and describe the clinical characteristics, treatment strategies, and survival outcomes of adult thalamic gliomas.

Methods

Relevant articles were identified on PubMed, Scopus, and Cochrane databases. Papers containing cases of adult thalamic gliomas with clinical outcome data were included. A comprehensive review of clinical characteristics and survival analysis was conducted.

Results

We included 25 studies comprising 617 patients. The median age was 45 years (male = 58.6%). Glioblastoma was the most frequent histological type (47.2%), and 82 tumors were H3 K27M-mutant. Motor deficit was the most common presenting symptom (51.8%). Surgical resection was performed in 69.1% of cases while adjuvant chemotherapy and radiotherapy were administered in 56.3% and 72.6%, respectively. Other treatments included laser interstitial thermal therapy, which was performed in 15 patients (2.4%). The lesion laterality (P = 0.754) and the surgical approach (P = 0.111) did not correlate with overall survival. The median progression-free survival was 9 months, and the overall two-year survival rate was 19.7%. The two-year survival rates of low-grade and high-grade thalamic gliomas were 31.0% and 16.5%, respectively. H3 K27M-mutant gliomas showed worse overall survival (P = 0.017).

Conclusion

Adult thalamic gliomas are associated with poor survival. Complete surgical resection is associated with improved survival rates but is not always feasible. H3 K27M mutation is associated with worse survival and a more aggressive approach should be considered for mutant neoplasms.

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Data availability

All authors confirm the appropriateness of all dataset and software used for supporting the conclusion.

References

  1. Niu X, Wang T, Zhou X et al (2020) Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years. J Neurooncol 147:377–386. https://doi.org/10.1007/s11060-020-03430-x

    Article  CAS  PubMed  Google Scholar 

  2. Louis DN, Perry A, Reifenberger G et al (2016) The 2016 World Health Organization classification of tumors of the central nervous system: a summary. Acta Neuropathol 131:803–820. https://doi.org/10.1007/s00401-016-1545-1

    Article  PubMed  Google Scholar 

  3. Karremann M, Gielen GH, Hoffmann M et al (2018) Diffuse high-grade gliomas with H3 K27M mutations carry a dismal prognosis independent of tumor location. Neuro Oncol 20:123–131. https://doi.org/10.1093/neuonc/nox149

    Article  CAS  PubMed  Google Scholar 

  4. Kelly PJ (1989) Stereotactic biopsy and resection of thalamic astrocytomas. Neurosurgery 25:185–195. https://doi.org/10.1227/00006123-198908000-00006

    Article  CAS  PubMed  Google Scholar 

  5. Kis D, Máté A, Kincses ZT et al (2014) The role of probabilistic tractography in the surgical treatment of thalamic gliomas. Oper Neurosurg 10:262–272. https://doi.org/10.1227/NEU.0000000000000333

    Article  Google Scholar 

  6. Qinglong G, Wei H, Biwu W et al (2020) Lateral or medial surgical approaches for thalamic gliomas resection? World Neurosurg 136:e90–e107. https://doi.org/10.1016/j.wneu.2019.11.108

    Article  PubMed  Google Scholar 

  7. Sanai N, Berger MS (2018) Surgical oncology for gliomas: the state of the art. Nat Rev Clin Oncol 15:112–125. https://doi.org/10.1038/nrclinonc.2017.171

    Article  PubMed  Google Scholar 

  8. Serra C, Türe H, Yaltırık CK et al (2020) Microneurosurgical removal of thalamic lesions: surgical results and considerations from a large, single-surgeon consecutive series. J Neurosurg. https://doi.org/10.3171/2020.6.JNS20524

    Article  PubMed  Google Scholar 

  9. Murayi R, Borghei-Razavi H, Barnett GH, Mohammadi AM (2020) Laser interstitial thermal therapy in the treatment of thalamic brain tumors: a case series. Oper Neurosurg 19:641–650. https://doi.org/10.1093/ons/opaa206

    Article  Google Scholar 

  10. Li Z, Wu H, Wu B et al (2020) Long term follow-up and outcomes in adult patients with thalamic gliomas. Clin Neurol Neurosurg 195:105888. https://doi.org/10.1016/j.clineuro.2020.105888

    Article  PubMed  Google Scholar 

  11. Page MJ, McKenzie JE, Bossuyt PM et al (2021) The PRISMA 2020 statement: an updated guideline for reporting systematic reviews. BMJ. https://doi.org/10.1136/bmj.n71

    Article  PubMed  PubMed Central  Google Scholar 

  12. J Howick, I Chalmers, P Glasziou, T Greenhalgh, C Heneghan, A Liberati, I Moschetti, B Phillips (2011) Explanation of the 2011 Oxford Centre for Evidence-Based Medicine (OCEBM) levels of evidence (background document). In: Oxford Cent. Evidence-Based Med. https://www.cebm.ox.ac.uk/resources/levels-of-evidence/ocebm-levels-of-evidence. Accessed 1 Feb 2021

  13. NIH: study quality assessment tools—quality assessment tool for case series studies. https://www.nhlbi.nih.gov/health-topics/study-quality-assessment-tools. Accessed 1 Feb 2021

  14. Menon G, Nair S, Sudhir J et al (2010) Bilateral thalamic lesions. Br J Neurosurg 24:566–571. https://doi.org/10.3109/02688691003777915

    Article  CAS  PubMed  Google Scholar 

  15. Aihara K, Mukasa A, Gotoh K et al (2014) H3F3A K27M mutations in thalamic gliomas from young adult patients. Neuro Oncol 16:140–146. https://doi.org/10.1093/neuonc/not144

    Article  CAS  PubMed  Google Scholar 

  16. Hawasli AH, Bagade S, Shimony JS et al (2013) magnetic resonance imaging-guided focused laser interstitial thermal therapy for intracranial lesions. Neurosurgery 73:1007–1017. https://doi.org/10.1227/NEU.0000000000000144

    Article  PubMed  Google Scholar 

  17. Waqar M, Hanif S, Rathi N et al (2014) Diagnostic challenges, management and outcomes of midline low-grade gliomas. J Neurooncol 120:389–398. https://doi.org/10.1007/s11060-014-1563-6

    Article  PubMed  Google Scholar 

  18. Cao L, Li C, Zhang Y, Gui S (2015) Surgical resection of unilateral thalamic tumors in adults: approaches and outcomes. BMC Neurol 15:229. https://doi.org/10.1186/s12883-015-0487-x

    Article  PubMed  PubMed Central  Google Scholar 

  19. Saito R, Kumabe T, Kanamori M et al (2017) Distant recurrences limit the survival of patients with thalamic high-grade gliomas after successful resection. Neurosurg Rev 40:469–477. https://doi.org/10.1007/s10143-016-0804-x

    Article  PubMed  Google Scholar 

  20. Zhang P, Wang X, Ji N et al (2016) Clinical, radiological, and pathological features of 33 adult unilateral thalamic gliomas. World J Surg Oncol 14:78. https://doi.org/10.1186/s12957-016-0820-x

    Article  PubMed  PubMed Central  Google Scholar 

  21. Akiyama Y, Ohtaki S, Komatsu K et al (2017) Intraoperative mapping and monitoring of the pyramidal tract using endoscopic depth electrodes. World Neurosurg 105:14–19. https://doi.org/10.1016/j.wneu.2017.05.048

    Article  PubMed  Google Scholar 

  22. Esquenazi Y, Moussazadeh N, Link TW et al (2018) Thalamic glioblastoma: clinical presentation, management strategies, and outcomes. Neurosurgery 83:76–85. https://doi.org/10.1093/neuros/nyx349

    Article  PubMed  Google Scholar 

  23. Meyronet D, Esteban-Mader M, Bonnet C et al (2017) Characteristics of H3 K27M-mutant gliomas in adults. Neuro Oncol 19:1127–1134. https://doi.org/10.1093/neuonc/now274

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Niu X, Wang T, Yang Y et al (2018) Prognostic factors for the survival outcome of bilateral thalamic glioma: an integrated survival analysis. World Neurosurg 110:e222–e230. https://doi.org/10.1016/j.wneu.2017.10.132

    Article  PubMed  Google Scholar 

  25. Fukami S, Nakajima N, Okada H et al (2018) Pathologic findings and clinical course of midline paraventricular gliomas diagnosed using a neuroendoscope. World Neurosurg 114:e366–e377. https://doi.org/10.1016/j.wneu.2018.02.185

    Article  PubMed  Google Scholar 

  26. El Ahmadieh TY, Plitt A, Kafka B et al (2019) H3 K27M mutations in thalamic pilocytic astrocytomas with anaplasia. World Neurosurg 124:87–92. https://doi.org/10.1016/j.wneu.2018.12.147

    Article  Google Scholar 

  27. Liu Y, Zhang Y, Hua W et al (2019) Clinical and molecular characteristics of thalamic gliomas: retrospective report of 26 cases. World Neurosurg 126:e1169–e1182. https://doi.org/10.1016/j.wneu.2019.03.061

    Article  PubMed  Google Scholar 

  28. Dono A, Takayasu T, Ballester LY, Esquenazi Y (2020) Adult diffuse midline gliomas: clinical, radiological, and genetic characteristics. J Clin Neurosci 82:1–8. https://doi.org/10.1016/j.jocn.2020.10.005

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Kelly PJ, Kall BA, Goerss S, Earnest F (1986) Computer-assisted stereotaxic laser resection of intra-axial brain neoplasms. J Neurosurg 64:427–439. https://doi.org/10.3171/jns.1986.64.3.0427

    Article  CAS  PubMed  Google Scholar 

  30. Hakim R, Loeffler JS, Anthony DC, Black PM (1997) Gangliogliomas in adults. Cancer 79:127–131. https://doi.org/10.1002/(SICI)1097-0142(19970101)79:1%3c127::AID-CNCR18%3e3.0.CO;2-6

    Article  CAS  PubMed  Google Scholar 

  31. Steiger H-J, Götz C, Schmid-Elsaesser R, Stummer W (2000) Thalamic astrocytomas: surgical anatomy and results of a pilot series using maximum microsurgical removal. Acta Neurochir 142:1327–1337. https://doi.org/10.1007/s007010070001

    Article  CAS  PubMed  Google Scholar 

  32. Gallina P, Francescon P, Cavedon C et al (2002) Stereotactic interstitial radiosurgery with a miniature X-ray device in the minimally invasive treatment of selected tumors in the thalamus and the Basal Ganglia. Stereotact Funct Neurosurg 79:202–213. https://doi.org/10.1159/000070833

    Article  PubMed  Google Scholar 

  33. Puget S, Crimmins DW, Garnett MR et al (2007) Thalamic tumors in children: a reappraisal. J Neurosurg Pediatr 106:354–362. https://doi.org/10.3171/ped.2007.106.5.354

    Article  Google Scholar 

  34. Ostrom QT, Patil N, Cioffi G et al (2020) CBTRUS statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro Oncol 22:iv1–iv96. https://doi.org/10.1093/neuonc/noaa200

    Article  PubMed  PubMed Central  Google Scholar 

  35. Brown TJ, Brennan MC, Li M et al (2016) Association of the extent of resection with survival in glioblastoma. JAMA Oncol 2:1460. https://doi.org/10.1001/jamaoncol.2016.1373

    Article  PubMed  PubMed Central  Google Scholar 

  36. Claus EB, Walsh KM, Wiencke JK et al (2015) Survival and low-grade glioma: the emergence of genetic information. Neurosurg Focus 38:E6. https://doi.org/10.3171/2014.10.FOCUS12367

    Article  PubMed  PubMed Central  Google Scholar 

  37. Ostrom QT, Cote DJ, Ascha M et al (2018) Adult glioma incidence and survival by race or ethnicity in the United States from 2000 to 2014. JAMA Oncol 4:1254–1262. https://doi.org/10.1001/jamaoncol.2018.1789

    Article  PubMed  PubMed Central  Google Scholar 

  38. Bender S, Tang Y, Lindroth AM et al (2013) Reduced H3K27me3 and DNA hypomethylation are major drivers of gene expression in K27M mutant pediatric high-grade gliomas. Cancer Cell 24:660–672. https://doi.org/10.1016/j.ccr.2013.10.006

    Article  CAS  PubMed  Google Scholar 

  39. Fontebasso AM, Liu X-Y, Sturm D, Jabado N (2013) Chromatin remodeling defects in pediatric and young adult glioblastoma: a tale of a variant histone 3 tail. Brain Pathol 23:210–216. https://doi.org/10.1111/bpa.12023

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  40. Lewis PW, Muller MM, Koletsky MS et al (2013) Inhibition of PRC2 activity by a gain-of-function H3 mutation found in pediatric glioblastoma. Science 340:857–861. https://doi.org/10.1126/science.1232245

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  41. Bernstein M, Hoffman HJ, Halliday WC et al (1984) Thalamic tumors in children. J Neurosurg 61:649–656. https://doi.org/10.3171/jns.1984.61.4.0649

    Article  CAS  PubMed  Google Scholar 

  42. Weller M, van den Bent M, Preusser M et al (2020) EANO guidelines on the diagnosis and treatment of diffuse gliomas of adulthood. Nat Rev Clin Oncol. https://doi.org/10.1038/s41571-020-00447-z

    Article  PubMed  PubMed Central  Google Scholar 

  43. Stark AM, Nabavi A, Mehdorn HM, Blömer U (2005) Glioblastoma multiforme—report of 267 cases treated at a single institution. Surg Neurol 63:162–169. https://doi.org/10.1016/j.surneu.2004.01.028

    Article  PubMed  Google Scholar 

  44. Hervey-Jumper SL, Berger MS (2016) Maximizing safe resection of low- and high-grade glioma. J Neurooncol 130:269–282. https://doi.org/10.1007/s11060-016-2110-4

    Article  PubMed  Google Scholar 

  45. MSK-IMPACT: A targeted test for mutations in both rare and common cancers. https://www.mskcc.org/msk-impact. Accessed 27 Apr 2021

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Funding

No funds, Grants, or other support was received.

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Authors and Affiliations

  1. Department of Neurological Surgery, Trauma Center, Gamma Knife Center, Cannizzaro Hospital, Catania, Italy

    Paolo Palmisciano

  2. Department of Neurological Surgery, Memorial Sloan Kettering Cancer Center, 1275 York Ave, New York, NY, 10065, USA

    Tarek Y. El Ahmadieh, Kenny Yu & Nelson S. Moss

  3. Texas A&M University College of Medicine, Houston, TX, USA

    Ali S. Haider

  4. King Abdullah International Medical Research Center, Riyadh, Saudi Arabia

    Othman Bin Alamer

  5. Department of Neurological Surgery, Massachusetts General Hospital, Boston, MA, USA

    Faith C. Robertson

  6. Department of Neurological Surgery, University of Texas Southwestern Medical Center, Dallas, TX, USA

    Aaron R. Plitt, Salah G. Aoun & Toral R. Patel

  7. Department of Neurological Surgery, Indiana University School of Medicine, Indianapolis, IN, USA

    Aaron Cohen-Gadol

  8. Department of Neurological Surgery, MD Anderson Cancer Center, Houston, TX, USA

    Raymond Sawaya

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  1. Paolo Palmisciano
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Contributions

PP—Conceptualization, methodology, data analysis, writing (original draft). TYEA—Conceptualization, methodology, writing (review & editing). ASH—Conceptualization, writing (review & editing). OBA—Methodology, writing (review & editing). FR—Methodology, writing (review & editing). ARP—Methodology, writing (review & editing). SGA—Methodology, writing (review & editing). KY—Methodology, writing (review & editing). ACG—Methodology, writing (review & editing). NSM—Methodology, writing (review & editing). TRP—Methodology, writing (review & editing). RS—Conceptualization, methodology, writing (review & editing).

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Correspondence to Tarek Y. El Ahmadieh.

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Palmisciano, P., El Ahmadieh, T.Y., Haider, A.S. et al. Thalamic gliomas in adults: a systematic review of clinical characteristics, treatment strategies, and survival outcomes. J Neurooncol 155, 215–224 (2021). https://doi.org/10.1007/s11060-021-03898-1

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