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Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years

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Abstract

Purpose

Given the rarity in the population with adult thalamic gliomas (ATGs), comprehensive characteristics, treatments and survival outcome are not well characterized. This study was conducted to investigate the comprehensive characteristic and treatment of ATGs and identify the prognostic factors associated with overall survival (OS).

Methods

A retrospective analysis of newly diagnosed ATGs who underwent surgical resection consecutively was conducted. Survival analysis of OS was performed by Kaplan–Meier analysis. Cox proportional hazard model was used to investigate the possible prognostic factors associated with OS.

Results

A total of 102 patients with ATG were enrolled in this study. The median age was 41 years (range 18–68 years). There were 56 (54.9%) males. Sixty-two patients (60.8%) had glioblastoma (GBM). Among these patients, 46 patients (45.1%) had GTR/NTR, 50 patients (49.0%) had STR and 6 patients (5.9%) had PR. Postoperatively, 71.6% of these patients received adjuvant therapy. The median OS was 13.6 months (range 1 week–75 months). COX regression analysis revealed that ATG patients with longer duration of symptoms (p = 0.024), better pre-KPS (p = 0.045), maximal resection (p = 0.013), or lower tumor grade (p = 0.002) had longer OS, and these predictors are considered as independent prognostic factors. Survival analysis showed that ATGs with GTR/NTR plus chemoradiotherapy had significant OS advantage compared with other treatment regimens.

Conclusions

This study comprehensively summarized the characteristics, treatments and survival outcomes of ATGs in the largest sample size. Maximal surgical resection can bring survival benefit. Combined-modality therapy regimen of GTR/NTR plus chemoradiotherapy may be better beneficial for OS than other regimens.

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Acknowledgements

This study was supported by the Key Research and Development Project of the Department of Science and Technology of Sichuan Province, China (Grant No. 2017SZ0006), Infrastructure Platform from the Department of Science and Technology of Sichuan Province, China (Grant Nos. 2016TJPT0012 and 2015JCPT0002) and Innovation and Sparkle Project of Sichuan University (Grant No. 2082604401004/060).

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Author notes

  1. Xiaodong Niu, Tianwei Wang, Xingwang Zhou, and Yuan Yang contributed equally to this work, and should be considered as co-first authors.

Authors and Affiliations

  1. Department of Neurosurgery, West China Hospital, Sichuan University, No. 37 Guo Xue Xiang, Chengdu, 610041, China

    Xiaodong Niu, Tianwei Wang, Xingwang Zhou, Yuan Yang, Xiang Wang, Haodongfang Zhang, Yuekang Zhang, Yanhui Liu & Qing Mao

  2. Department of Pathology, West China Hospital, Sichuan University, Chengdu, 610041, China

    Ni Chen

  3. Department of Radiology, West China Hospital, Sichuan University, Chengdu, 610041, China

    Qiang Yue

  4. Department of Oncology, West China Hospital, Sichuan University, Chengdu, 610041, China

    Feng Wang

  5. West China Glioma Centre, West China Hospital, Sichuan University, Chengdu, 610041, China

    Yuan Yang, Xiang Wang, Ni Chen, Qiang Yue, Feng Wang, Yanhui Liu & Qing Mao

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  1. Xiaodong Niu
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Correspondence to Yanhui Liu or Qing Mao.

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Niu, X., Wang, T., Zhou, X. et al. Surgical treatment and survival outcome of patients with adult thalamic glioma: a single institution experience of 8 years. J Neurooncol 147, 377–386 (2020). https://doi.org/10.1007/s11060-020-03430-x

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