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Tumor location-based classification of surgery-related language impairments in patients with glioma

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A Correction to this article was published on 12 October 2021

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Abstract

Introduction

Many patients with glioma experience surgery-related language impairment. This study developed a classification system to predict postoperative language prognosis.

Methods

Sixty-eight patients were retrospectively reviewed. Based on their location, tumors were subtyped as follows: (I) inferior frontal lobe or precentral gyrus; (II) posterior central gyrus or supramarginal gyrus (above the lateral fissure level); (III) posterior region of the superior or middle temporal gyri or supramarginal gyrus (below the lateral fissure level); and (IV) insular lobe. The distance from the tumor to the superior longitudinal fasciculus/arcuate fasciculus was calculated. The recovery of language function was assessed using the Western Aphasia Battery before surgery, and a comprehensive language test was conducted on the day of surgery; 3, 7, and 14 days after surgery. Our follow-up information of was the comprehensive language test from telephone interviews in 3 months after surgery.

Results

Thirty-three patients experienced transient language impairment within 1 week of surgery. Fourteen patients had permanent language impairment. Type II tumors, shorter distance from the tumor to the posterior superior longitudinal fasciculus/arcuate fasciculus, and isocitrate dehydrogenase mutations were risk factors for surgery-related language impairment. Regarding the presence or absence of permanent surgery-related language impairments, the cut-off distance between the tumor and posterior superior longitudinal fasciculus/arcuate fasciculus was 2.75 mm.

Conclusions

According to our classification, patients with type II tumors had the worst language prognosis and longest recovery time. Our classification, based on tumor location, can reliably predict postoperative language status and may be used to guide tumor resection.

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Anonymized data will be made available on request.

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Acknowledgements

We would like to thank Dr. Lanxi Meng for imaging data acquisition for this study.

Funding

This study was supported by funds from Public Welfare Development and Reform Pilot Project of Beijing Medical Research Institute (PXM2019_026280_000008), Beijing Municipal Natural Science Foundation (No. 7202021), National Natural Science Foundation of China (No. 82001777), and Brain Tumor Precision Diagnosis and Treatment and Translational Medicine Innovation Unit, Chinese Academy of Medical Sciences (2019-I2M-5-021).

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Authors and Affiliations

  1. Beijing Neurosurgical Institute, Capital Medical University, 119, the Western Road of the southern 4th Ring Road, Beijing, 100070, China

    Shengyu Fang, Yuchao Liang, Lianwang Li, Xing Fan & Tao Jiang

  2. Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical University, 119, the Western Road of the southern 4th Ring Road, Beijing, 100070, China

    Shengyu Fang, Lianwang Li, Lei Wang, Yinyan Wang & Tao Jiang

  3. Research Unit of Accurate Diagnosis, Treatment, and Translational Medicine of Brain Tumors Chinese Academy of Medical Sciences, Beijing, China

    Tao Jiang

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  1. Shengyu Fang
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Contributions

Study concept and design: SF, YL, and LL. Data acquisition and analysis: SF, YL, and LL. Statistical analyses/verified the analytical method: SF, YL, and YW. Writing the first draft: SF, XF, and YW. Supervision study: XF, YW, and TJ. Read and approved final version: All authors.

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Correspondence to Xing Fan, Yinyan Wang or Tao Jiang.

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This study was approved by the IRB of Beijing Tiantan Hospital.

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All participants provided informed written consent before data acquisition.

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Fang, S., Liang, Y., Li, L. et al. Tumor location-based classification of surgery-related language impairments in patients with glioma. J Neurooncol 155, 143–152 (2021). https://doi.org/10.1007/s11060-021-03858-9

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