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A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk

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Abstract

The associations of the X-ray repair cross complementing group 1 (XRCC1) gene single nucleotide polymorphisms (SNPs) Arg194Trp, Arg280His, Arg399Gln with the risk of gliomas have been studied recently, but contradictions exist whether the XRCC1 SNPs were a risk factor. We examined these associations by performing a meta-analyse. Nine studies tested the associations between XRCC1 SNPs and gliomas were retrieved. Overall odds ratios (ORs) and corresponding 95 % confidence intervals were estimated using genetic models. Heterogeneity and publication bias were evaluated. The pooled OR for Arg194Trp TT versus CC were significant, which was 2.208 (95 % CI: 1.099, 4.435; P = 0.026), but it was non-significant after removal of the studies which deviated from the Hardy–Weinberg equilibrium (HWE). The pooled OR for Arg399Gln AA+GA versus GG of genotype methods subgroup and the low study appraisal score subgroup were significant in the stratification analysis, but the meta-regression results were non-significance. No significant associations were found between the Arg280His SNPs and gliomas’ risk. There was no evidence of publication bias. We conclude that SNPs in XRCC1 are not associated with the risk of gliomas. We should do more work on the relevant variants like those in TERT, RTEL1, EGFR, CDKN2A, CCDC26, and PHLDB1 and their products rather than the XRCC1. More GWAS will also need to involve sufficiently larger study populations along with analysis of tumor or gender subtypes in order to assess these risks.

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Abbreviations

ADP:

Poly-adenosine diphosphate-ribose polymerase

ADPRT:

Adenosine diphosphate ribosyl transferase

BER:

Base excision repair

CI:

Confidence interval

GWAS:

Genome-wide association study

HWE:

Hardy–Weinberg equilibrium

OR:

Odds ratios

PCR:

Polymerase chain reaction

RFLP:

Restriction fragment length polymorphism

SNPs:

Single nucleotide polymorphisms

XPD:

Eroderma pigmentosum complementary group D

XRCC1:

X-ray repair cross complementing 1 gene

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Acknowledgments

We would like to express our great gratitude to Professor Ali Khonsary, Department of Veterans Affairs Medical Center, West Los Angeles, U.S.A, for his helpful edition and critically comments.

Conflict of interest

Research reported in this article received no funding and We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work, there is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the review of the manuscript.

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Authors and Affiliations

  1. Department of Neurosurgery, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunnan, China

    Mengjun Li, Qian Zhou & Yugang Jiang

  2. Metabolic Syndrome Research Center, The Second Xiangya Hospital of Central South University, Changsha, 410011, Hunnan, China

    Chao Tu

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  1. Mengjun Li
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  2. Qian Zhou
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Correspondence to Yugang Jiang.

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Li, M., Zhou, Q., Tu, C. et al. A meta-analysis of an association between the XRCC1 polymorphisms and gliomas risk. J Neurooncol 111, 221–228 (2013). https://doi.org/10.1007/s11060-012-1022-1

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  • DOI: https://doi.org/10.1007/s11060-012-1022-1

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