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The roles of viruses in brain tumor initiation and oncomodulation

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Abstract

While some avian retroviruses have been shown to induce gliomas in animal models, human herpesviruses, specifically, the most extensively studied cytomegalovirus, and the much less studied roseolovirus HHV-6, and Herpes simplex viruses 1 and 2, currently attract more and more attention as possible contributing or initiating factors in the development of human brain tumors. The aim of this review is to summarize and highlight the most provoking findings indicating a potential causative link between brain tumors, specifically malignant gliomas, and viruses in the context of the concepts of viral oncomodulation and the tumor stem cell origin.

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Acknowledgments

We thank Chris Letson for reading and correcting the manuscript. Supported by NIH RO1 NS045209 (R. Abounader) and NIH R01 CA134843 (R. Abounader).

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Authors and Affiliations

  1. Department of Microbiology, University of Virginia, P.O. Box 800168, Charlottesville, VA, 22908, USA

    Alexander Kofman, Lucasz Marcinkiewicz, Evan Dupart, Jay Brown & Roger Abounader

  2. Department of Cancer Center, University of Virginia, Charlottesville, VA, USA

    David Schiff & Roger Abounader

  3. St. Petersburg State Department of Health, Laboratory of Molecular Genetics, Hospital #31, Pr. Dinamo 3, St. Petersburg, 197110, Russia

    Anton Lyshchev & Elena Kotelevskaya

  4. S.M.Kirov Medical Academy, Pr. Dinamo 3, St. Petersburg, 197110, Russia

    Boris Martynov

  5. Clinical Diagnostic Center, Pr. Dinamo 3, St. Petersburg, 197110, Russia

    Anatolii Ryndin

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  1. Alexander Kofman
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  2. Lucasz Marcinkiewicz
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  3. Evan Dupart
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  4. Anton Lyshchev
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  8. Jay Brown
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  9. David Schiff
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  10. Roger Abounader
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Correspondence to Roger Abounader.

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Kofman, A., Marcinkiewicz, L., Dupart, E. et al. The roles of viruses in brain tumor initiation and oncomodulation. J Neurooncol 105, 451–466 (2011). https://doi.org/10.1007/s11060-011-0658-6

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  • DOI: https://doi.org/10.1007/s11060-011-0658-6

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