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Glioblastoma simultaneously present with adjacent meningioma: case report and review of the literature

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Abstract

The simultaneous occurrence of multiple primary intracranial tumors has been reported previously. However, most of these tumors arise after cranial radiotherapy or in association with familial tumor syndromes. Double tumors of different histologies that are unrelated to radiotherapy or genetic disorders are very rare. We present a case of two primary intracranial tumors occurring simultaneously at adjacent sites. Preoperative gadolinium-enhanced magnetic resonance imaging of these tumors revealed a single continuous lesion. Postoperative histological examination revealed the presence of two distinct tumors, meningioma and glioblastoma multiforme. To elucidate the mechanism of synchronous tumor formation, we performed immunohistochemical analysis of the proteins involved in the receptor tyrosine kinase, Wnt, and Notch signaling pathways. These analyses showed that platelet-derived growth factor (PDGF) receptors-α and β were overexpressed in both tumors, thereby indicating the oncogenic effects of activated signaling of these receptors. The PDGF-mediated paracrine system may induce one tumor from another.

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Acknowledgment

The authors thank Tamio Ito of Nakamura Memorial Hospital (Sapporo, Japan) for permitting the use of the cerebral angiography images; Hiroko Asanuma, Yuko Matsushita, and Yoshitaka Narita for histotechnology support.

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Author notes

  1. Hiroyuki Momota

    Present address: Department of Neurosurgery, Graduate School of Medicine, Nagoya University, 65, Tsurumai-cho, Showa-ku, Nagoya, 466-8550, Japan

Authors and Affiliations

  1. Department of Neurosurgery, Sapporo Medical University School of Medicine, South-1, West-16, Chuo-ku, Sapporo, 060-8543, Japan

    Kengo Suzuki, Hiroyuki Momota, Kouhei Yamamoto, Masahiko Wanibuchi, Yoshihiro Minamida & Kiyohiro Houkin

  2. Department of Surgical Pathology, Sapporo Medical University School of Medicine, Sapporo, Japan

    Akiko Tonooka, Hiroko Noguchi & Tadashi Hasegawa

Authors
  1. Kengo Suzuki
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  2. Hiroyuki Momota
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Correspondence to Hiroyuki Momota.

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Suzuki, K., Momota, H., Tonooka, A. et al. Glioblastoma simultaneously present with adjacent meningioma: case report and review of the literature. J Neurooncol 99, 147–153 (2010). https://doi.org/10.1007/s11060-009-0109-9

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  • DOI: https://doi.org/10.1007/s11060-009-0109-9

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