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Meningiomas expressing and responding to cholecystokinin (CCK)

  • Laboratory Investigation
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Abstract

The effect of cholecystokinin (CCK) on cultured human meningioma derived cells was investigated. Exposure of meningioma cells for 6–12 days to CCK-8s (2–200 nM) resulted in a dose dependent stimulation of cell growth to a maximum of 1.1-fold over basal controls. A time course study showed stimulation of cell growth at day 3 followed by increase throughout day 6. The stimulatory effect of CCK on meningioma cell growth was completely abolished by a CCK-B specific receptor antagonist, L-365,260. Reverse-transcription of meningioma-derived RNA into cDNA followed by amplification by the polymerase chain reaction using specific primers for CCK peptide and its CCK-A and/B receptor revealed 100% presence of CCK peptide and CCK-B receptors mRNA whereas CCK-A receptor was expressed in 66% of the meningiomas. These results provide evidence that human meningioma cells possess CCK peptide and its receptors the activation of which leads to increase of cell growth possibly via an autocrine/paracrine mechanism.

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Authors and Affiliations

  1. School of Health and Life Sciences, Biomedical Chemistry Research Group, Aston University, B4 7ET, Birmingham, UK

    Eftychia Oikonomou & Eric F. Adams

  2. Department of Neurosurgery, University of Goettingen, Germany

    Ana L. Machado & Michael Buchfelder

Authors
  1. Eftychia Oikonomou
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  2. Ana L. Machado
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  3. Michael Buchfelder
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  4. Eric F. Adams
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Correspondence to Eric F. Adams.

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Oikonomou, E., Machado, A.L., Buchfelder, M. et al. Meningiomas expressing and responding to cholecystokinin (CCK). J Neurooncol 73, 199–204 (2005). https://doi.org/10.1007/s11060-004-5177-2

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  • DOI: https://doi.org/10.1007/s11060-004-5177-2

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