The aim of the present study was, within the framework of the concept of “clinical high risk for psychosis,” to identify functional characteristics of the brain (based on resting-state fMRI data) and neuropsychological characteristics in 27 patients with non-psychotic mental disorders, with attenuated schizophrenia symptoms which had not converted during a long observation period, as compared with 24 patients with first-episode schizophrenia, and 27 mentally healthy subjects. The main group was characterized by higher levels pf BOLD coherence in the visual cortex of the right hemisphere and higher functional connectivity between the occipital component of the visual network and a salience network component in the right prefrontal cortex (as compared with schizophrenia patients). Both groups of patients showed decreased productivity in verbal fluency tests. The neuroimaging and neuropsychological peculiarities of patients in the main group identified here can be regarded as reflecting an impact of “protective” and “pathological” mechanisms in patients at high risk for schizophrenia.
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Lebedeva, I.S., Panikratova, Y.R., Abdullina, E.G. et al. Neuroimaging (Resting-State fMRI) and Neuropsychological Characteristics of Non-Converted Patients from a Group at Clinical High Risk for Schizophrenia. Neurosci Behav Physi 53, 1449–1458 (2023). https://doi.org/10.1007/s11055-023-01538-x
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DOI: https://doi.org/10.1007/s11055-023-01538-x