The comorbidity of refractory depression and chronic pain is actively discussed in the scientific literature. The present article compares the efficacies of two TMS protocols added to drug therapy for refractory depression with comorbid chronic pain. Stimulation of the left and right dorsolateral prefrontal cortex was shown to have different effects on pain and depressive symptoms. High-frequency stimulation of the left dorsolateral prefrontal cortex was found to have progressive antidepressant and analgesic effects, while low-frequency stimulation of the right dorsolateral prefrontal cortex had a rapid analgesic effect, which decreased after completion of courses. The results obtained here clarify the neurophysiological basis of pain perception and the formation of mood in mental disorders.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 72, No. 5, pp. 717–727, September–October, 2022.
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Petelin, D.S., Bezrukov, V.E., Shishorin, R.M. et al. Comparison of the Effectiveness of Transcranial Magnetic Stimulation Protocols as an Adjunct to the Pharmacotherapy of Refractory Depression with Comorbid Chronic Pain. Neurosci Behav Physi 53, 365–372 (2023). https://doi.org/10.1007/s11055-023-01435-3
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DOI: https://doi.org/10.1007/s11055-023-01435-3