This article addresses studies of the developmental morphofunctional properties of areas of the prefrontal cortex of adolescents involved in visual (frontal oculomotor field 8) and speech motor (fields 44 and 45 of Broca’s area) functions, as well as the cortex in the area of the lateral surface of the frontal pole (field 10) and the medial paralimbic part of the prefrontal cortex (field 32/10). Autopsy specimens were obtained from 60 people (52 male and eight female) of three age groups: I) children from 8 to 12 years of age (n = 30), II) adolescents aged 13–16 years (n = 15), and III) young adults aged 17–21 years (n = 15). Pyramidal neuron size was evaluated in layers III and V of the cortex, along with fibroarchitectonics, specific volumes of neurons and intracortical fibers; the gliovascular index was determined. Histological methods were used, with computerized morphometric and stereological analysis. The study results showed that developmental microstructural changes in the prefrontal cortex were seen in adolescents, leading to increases in the complexity of its morphofunctional organization as compared with children.
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Antonova, A. M. and Stepanova, S. B., “A modification of the Peters method for cytological studies,” Byull. Eksperim. Biol., 75, No. 4, 122–124 (1973).
Antonova, A. M., “A modification of the Golgi method using sodium tungstate,” Byull. Eksperim. Biol., 63, No. 3, 123–124 (1967).
Avtandilov, G. G., Medical Morphometry, Medicine, Moscow (1990).
Baars, B. J. and Gage, N. M., “Neurons and their connections,” in: Cognition, Brain, and Consciousness. Introduction to Cognitive Neuroscience, Elsevier, Academic Press (2010), 2nd ed., pp. 62–92, https://doi.org/10.1016/C2009-0-01556-6.
Beskin, L. N., Stereometry, Prosveshchenie, Moscow (1971).
Bezrukikh, M. M. and Farber, D. A. (eds.), Physiology of Child Development, MPSI, MODEK, Voronezh (2010).
Blakemore, S. J., “Imaging brain development: the adolescent brain,” NeuroImage, 61, No. 2, 397–406 (2012), https://doi.org/10.1016/j.neuroimage.2011.11.080.
Bogolepova, I. N. and Malofeeva, L. I., Male Brain, Female Brain, National Neurology Center of the Russian Academy of Medical Sciences, Moscow (2014).
Bogolepova, I. N., Malofeeva, L. I., Agapov, P. A., and Malofeeva, I. G., “Morphometric studies of the cytoarchitectonics of the prefrontal cortex of the brain in women,” Fundament. Issled., 2, No. 25, 5583–5587 (2015).
Chen, C. H., Panizzon, M. S., Eyler, L. T., et al., “Genetic influences on cortical regionalization in the human brain,” Neuron, 72, No. 4, 537–544 (2011), https://doi.org/10.1016/j.neuron.2011.08.021.
Docherty, A. R., Sawyers, C. K., Panizzon, M. S., et al., “Genetic network properties of the human cortex based on regional thickness and surface area measures,” Front. Hum. Neurosci., 9, 440 (2015), https://doi.org/10.3389/fnhum.2015.00440.
Dubois, J., Dehaene-Lambertz, G., Perrin, M., et al., “Asynchrony of the early maturation of white matter bundles in healthy infants: quantitative landmarks revealed noninvasively by diffusion tensor imaging,” Hum. Brain Mapp., 29, No. 1, 14–27 (2008a), https://doi.org/10.1002/hbm.20363.
Dubois, J., Dehaene-Lambertz, G., Soares, C., et al., “Microstructural correlates of infant functional development: example of the visual pathways,” J. Neurosci., 28, No. 8, 1943–1948 (2008b), https://doi.org/10.1523/JNEUROSCI.5145-07.2008.
Dumontheil, I., Burgess, P. W., and Blakemore, S. J., “Development of rostral prefrontal cortex and cognitive and behavioural disorders,” Dev. Med. Child Neurol., 50, No. 3, 168–181 (2008), https://doi.org/10.1111/j.1469-8749.2008.02026.x.
Farber, D. A. and Beteleva, T. G., “Formation of the cerebral organization of working memory at young school age,” Fiziol. Cheloveka, 37, No. 1, 5–15 (2011).
Farber, D. A., “Systems organization of visual perception and its formation during ontogeny,” in: Cerebral Mechanisms of the Formation of Cognitive Activity at Preschool and Early School Age, MPSU, MODEK, Voronezh (2014), pp. 65–95.
Filosa, J. and Alddings, J., “Astrocyte regulation of cerebral vascular tone,” Am. J. Physiol. Heart Circ. Physiol., 305, No. 5, H609–H619 (2013), https://doi.org/10.1152/ajpheart.00359.2013.
Gerbella, M., Belmalih, A., Borra, E., et al., “Cortical connections of the macaque caudal ventrolateral prefrontal areas 45A and 45B,” Cereb. Cortex, 20, No. 1, 141–168 (2010), https://doi.org/10.1093/cercor/bhp087.
Kanwisher, N., “Functional specificity in the human brain: a window into the functional architecture of the mind,” Proc. Natl. Acad. Sci. USA, 107, No. 25, 11163–11170 (2010), https://doi.org/10.1073/pnas.1005062107.
Kedlian, V. R., Donertas, H. M., and Thornton, J. M., “The widespread increase in inter-individual variability of gene expression in the human brain with age,” Aging (Albany NY), 11, No. 8, 2253–2280 (2019), https://doi.org/10.18632/aging.101912.
Khundrakpam, B. S., Reid, A., Brauer, J., et al., “Developmental changes in organization of structural brain networks,” Cereb. Cortex, 23, No. 9, 2072–2085 (2013), https://doi.org/10.1093/cercor/bhs187.
Kostovic, I. and Judas, M., “Prolonged coexistence of transient and permanent circuitry elements in the developing cerebral cortex of fetuses and preterm infants,” Dev. Med. Child. Neurol., 48, No. 5, 388–393 (2006), https://doi.org/10.1017/S0012162206000831.
Lang, T. A. and Sesik, M., How to Describe Statistics in Medicine, Practical Medicine, Moscow (2016).
Leh, S. E., Petrides, M., and Strafella, A. P., “The neural circuitry of executive functions in healthy subjects and Parkinson’s disease,” Neuropsychopharmacology, 35, No. 1, 70–85 (2010), https://doi.org/10.1038/npp.2009.88.
Machinskaya, R. I., “Control systems of the brain and their morphofunctional maturation in children,” in: Cerebral Mechanisms of the Formation of Cognitive Activity at Preschool and Early School Age, MPSU, MODEK, Voronezh (2014), pp. 157–220.
Machinskaya, R. I., “Control systems of the brain,” Zh. Vyssh. Nerv. Deyat., 65, No. 1, 33–60 (2015), https://doi.org/10.7868/S0044467715010086.
Mansouri, F. A., Matsumoto, K., and Tanaka, K., “Prefrontal cell activities related to monkeys’ success and failure in adapting to rule changes in a Wisconsin Card Sorting Test analog,” J. Neurosci., 26, No. 10, 2745–2756 (2006), https://doi.org/10.1523/JNEUROSCI.5238-05.2006.
Margulies, D. S. and Petrides, M., “Distinct parietal and temporal connectivity profiles of ventrolateral frontal areas involved in language production,” J. Neurosci., 33, No. 42, 16846–16852 (2013), https://doi.org/10.1523/JNEUROSCI.2259-13.2013.
Markosyan, A. A., Basic Morphology and Physiology of Children and Adolescents, Medicine, Moscow (1969).
Nip, I. S. B. and Green, J. R., “Increases in cognitive and linguistic processing primarily account for increases in speaking rate with age,” Child Dev., 84, No. 4, 1324–1337 (2013), https://doi.org/10.1111/cdev.12052.
Paus, T., Zijdenbos, A., Worsley, K., et al., “Structural maturation of neural pathways in children and adolescents: In vivo study,” Science, 283, No. 5409, 1908–1911 (1999), https://doi.org/10.1126/science.283.5409.1908.
Pessoa, L., “Understanding brain networks and brain organization,” Phys. Life Rev., 11, No. 3, 400–435 (2014), https://doi.org/10.1016/j.plrev.2014.03.005.
Sarkisov, S. A. Filimonov, I. N., Kononova, E. P., et al. (eds.), Cytoarchitectonic Atlas of the Human Cerebral Cortex, Medgiz, Moscow (1955).
Semenova, L. K., Vasil’eva, V. A., Tsekhmistrenko, T. A., and Shumeiko, N. S., “Structural transformations in the human cerebral cortex during postnatal ontogeny,” in: The Physiology of Child Development, MPSI, MODEK, Moscow, Voronezh (2010), pp. 132–200.
Senitz, D., Reichenbach, A., and Smithy, T. G., “Surface complexity of human neocortical astrocytic cells: changes with development, aging and dementia,” J. Hirnforsch., 36, No. 4, 531–537 (1995).
Stefanov, S. B. and Kukharenko, N. S., Accelerated Methods for Quantitative Comparison of Morphological Features and Systems, VSKhI, Blagoveshchensk (1989).
Strelkov, R. B., An Express Method for Statistical Processing of Experimental and Clinical Data, II MOLGMI, Moscow (1986).
Tsekhmistrenko, T. A., Obukhov, D. K., Vasil’eva, V. A., et al., “Structural developmental transformations of neuron groups in the cerebral cortex and cerebellum in children,” Zh. Anat. Histopatol., 8, No. 4, 42–48 (2019b).
Tsekhmistrenko, T. A., Vasil’eva, V. A., Obukhov, D. K., and Shumeiko, N. S., Structure and Development of the Cerebral Cortex, Sputnik+, Moscow (2019a).
Tsekhmistrenko, T. A., Vasil’eva, V. A., Shumeǐko, N. S., and Vologirov, A. S., “Quantitative changes in fibro-architectonics of the human cerebral cortex from birth to 12 years of age,” Neurosci. Behav. Physiol., 34, No. 9, 983–988 (2004), https://doi.org/10.1134/S0362119710010032.
Tsekhmistrenko, T. A., Vasilyeva, V. A., and Shumeiko, N. S., “Structural rearrangements of the cerebral cortex in children and adolescents,” Hum. Physiol., 43, No. 2, 123–131 (2017), https://doi.org/10.1134/S0362119717020153.
Van den Heuvel, M. P. and Sporns, O., “Rich-club organization of the human connectome,” J. Neurosci., 31, No. 44, 15775–15786 (2011), https://doi.org/10.1523/JNEUROSCI.3539-11.2011.
Venkat, P., Chopp, M., and Chen, J., “New insights into coupling and uncoupling of cerebral blood flow and metabolism in the brain,” Croat Med. J., 57, No. 3, 223–228 (2016), https://doi.org/10.3325/cmj2016.57.223.
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 71, No. 5, pp. 591–604, September–October, 2021.
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Tsekhmistrenko, T.A. Morphofunctional Approach to Studies of the Properties of the Prefrontal Cortex in Adolescents. Neurosci Behav Physi 52, 521–530 (2022). https://doi.org/10.1007/s11055-022-01272-w
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DOI: https://doi.org/10.1007/s11055-022-01272-w