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Effects of Auditory LTP-Like Stimulation on Auditory Stimulus Processing

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High-frequency electrical stimulation induces increases in synchronous transmission between pairs of neurons which persists for prolonged periods (long-term potentiation, LTP). Recent studies showed that sensory (so-called LTP-like, with a frequency of over 9 Hz) stimulation can induce effects analogous to those seen after electrical stimulation and typical of LTP. Some human studies using the auditory modality have shown that LTP-like stimulation is followed by increases in the N1 component, which reflects the representation of the physical characteristics of the signal in the auditory cortex, and the MMN component, linked with signal discriminability. The present study supplements previous research by addressing the effects of stimulation not only immediately after stimulation but also at a subsequent visit to the laboratory. We used a passive oddball paradigm with two rare (10% each) deviant tones (980 and 1020 Hz) and a standard (80%) tone (1000 Hz). This paradigm was presented three times: before (control series), immediately after LTP-like stimulation, and at 7–35 days. LTP-like stimulation was delivered using a tone at 1020 Hz presented for 3 min with sinusoidal amplitude modulation at a frequency of 26 Hz. Immediately after stimulation, the N1 component decreased in response to stimuli at 980 Hz and 1000 Hz, while this component showed no change in responses to the stimuli used for stimulation (1020 Hz). We suggest that this may be linked with the mechanism of lateral inhibition. However, the effect was already missing at the second visit to the laboratory, though an increase in N1 amplitude in response to stimuli at 1020 Hz was recorded, which may be evidence of a long-term “potentiation” effect for the stimulating tone. Differences in MMN were not seen. Thus, we found plastic rearrangements in the auditory cortex induced by LTP-like stimulation which may underlie learning.

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Authors and Affiliations

  1. Sirius University of Science and Technology, Sochi, Russia

    A. B. Rebreikina, D. F. Kleeva, G. A. Soghoyan & O. V. Sysoeva

  2. Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, Russia

    A. B. Rebreikina, G. A. Soghoyan & O. V. Sysoeva

  3. National Research University Higher School of Economics (HSE), Moscow, Russia

    D. F. Kleeva & G. A. Soghoyan

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  1. A. B. Rebreikina
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  2. D. F. Kleeva
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  3. G. A. Soghoyan
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  4. O. V. Sysoeva
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Correspondence to A. B. Rebreikina.

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Translated from Sensornye Sistemy, Vol. 35, No. 2, 144–152, April–June, 2021.

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Rebreikina, A.B., Kleeva, D.F., Soghoyan, G.A. et al. Effects of Auditory LTP-Like Stimulation on Auditory Stimulus Processing. Neurosci Behav Physi 51, 1323–1329 (2021). https://doi.org/10.1007/s11055-021-01197-w

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