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A Prognostic Model of the Development of Cognitive Impairments in Patients with Type 1 Diabetes Mellitus

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Objective. TO develop a prognostic model of the development of cognitive impairments in patients with type 1 diabetes mellitus using proton magnetic resonance spectroscopy data. Materials and methods. The study included patients with type 1 diabetes mellitus (DM) and people without DM (control group). Carbohydrate metabolism was assessed in all participants, and all underwent neuropsychological testing (using the MoCA test) and proton magnetic resonance spectroscopy of the brain. Results were analyzed statistically in IBM SPSS Statistics 20.0. The prognostic model was computed by discriminant analysis. Results. Proton magnetic resonance spectroscopy data and discriminant analysis yielded a prognostic model for the development of cognitive impairments in patients with type 1 diabetes mellitus. Conclusions. The method developed here for the early diagnosis of cognitive impairments provides early prognostication of the development of cognitive impairments in patients with type 1 diabetes mellitus and can be used in clinical practice to assess the efficacy of treatment used for the prophylaxis of cognitive impairment.

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Authors and Affiliations

  1. Siberian State Medical University, Russian Ministry of Health, Tomsk, Russia

    Yu. G. Samoilova, M. A. Rotkank, N. G. Zhukova, M. V. Matveeva & I. V. Tolmachev

  2. Advanced Training Institute, Russian Federal Medical Biological Agency, Moscow, Russia

    D. A. Kudlay

  3. Institute of Immunology, Russian Federal Medical Biological Agency, Moscow, Russia

    D. A. Kudlay

Authors
  1. Yu. G. Samoilova
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  2. M. A. Rotkank
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  3. D. A. Kudlay
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  4. N. G. Zhukova
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  5. M. V. Matveeva
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  6. I. V. Tolmachev
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Corresponding author

Correspondence to M. A. Rotkank.

Additional information

Translated from Zhurnal Nevrologii i Psikhiatrii imeni S. S. Korsakova, Vol. 120, No. 3, Iss. 1, pp. 19–22, March, 2020.

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Samoilova, Y.G., Rotkank, M.A., Kudlay, D.A. et al. A Prognostic Model of the Development of Cognitive Impairments in Patients with Type 1 Diabetes Mellitus. Neurosci Behav Physi 50, 1136–1139 (2020). https://doi.org/10.1007/s11055-020-01015-9

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  • DOI: https://doi.org/10.1007/s11055-020-01015-9

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