The aim of the present work was to investigate a series of single-nucleotide gene polymorphisms and their associations with accident proneness in bus drivers. The study involved 299 shift-working professional drivers for whom accident statistics were available. Polymorphisms in genes associated with the sleep-waking rhythm and cognitive and emotional functions were investigated, i.e., CLOCK (rs12649507), RORA (rs1159814), NPAS2 (rs4851377), NPSR1 (rs324981), PER3 (rs2640909), DRD3 (rs6280), SLC6A3 (rs6347), and DBH (rs1611125). The study identifi ed signifi cant associations between accident parameters and polymorphisms in the CLOCK, NPSR1, and SLC6A3 genes. We suggest that these are due to differences in chronotype and resistance to impairments to the sleep regime for the CLOCK gene and in cognitive and emotional control for the NPSR1 and SLC6A3 genes.
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Allebrandt, K. V., Teder-Laving, M., Akyol, M., et al., “CLOCK gene variants associate with sleep duration in two independent populations,” Biol. Psychiatry, 67, No. 11, 1040–1047 (2010).
Barrash, J., Stillman, A., Anderson, S. W., et al., “Prediction of driving ability with neuropsychological tests: demographic adjustments diminish accuracy,” J. Int. Neuropsychol. Soc., 16, No. 4, 679–686 (2010).
Chua, E. C.-P., Yeo, S.-C., Lee, I. T.-G., et al., “Individual differences in physiologic measures are stable across repeated exposures to total sleep deprivation,” Physiol. Rep., 2, No. 9, e12129 (2014).
Dorokhov, V. B., Puchkova, A. N., Taranov, A. O., et al., “Circadian and sleep-related gene polymorphisms are associated with chronotypes and road accident history in professional bus drivers,” Neurosci. Meet. Plan., Society for Neuroscience, Washington, DC (2015), Program No. 2, 167.30/V21.
Gafarov, V. V., Gromova, E. A., Gagulin, I. V., et al., “Polymorphism in the neuropeptide S receptor gene (NPSR1) and its association with sleep disturbance in an open population of men,” Mir Nauki, Kult., Obraz., 54, No. 5, 275–277 (2015).
Goel, N., Basner, M., Rao, H., and Dinges, D. F., “Circadian rhythms, sleep deprivation, and human performance,” Prog. Mol. Biol. Transl. Sci., 119, 155–190 (2013).
Hu, Y., Shmygelska, A., Tran, D., et al., “GWAS of 89,283 individuals identifi es genetic variants associated with self-reporting of being a morning person,” Nat. Commun., 7, 10448 (2016).
Johnson, K., Patel, S., Baur, D., et al., “Association of sleep habits with accidents and near misses in United States transportation operators,” J. Occup. Environ. Med., 56, No. 5, 510–515 (2014).
Kiroi, V. N. and Aslanyan, E. V., “Common patterns in the formation of the state of monotony,” Zh. Vyssh. Nerv. Deyat., 55, No. 6, 768–776 (2005).
Laas, K., Eensoo, D., Paaver, M., et al., “Further evidence for the association of the NPSR1 gene A/T polymorphism (Asn10711e) with impulsivity and hyperactivity,” J. Psychopharmacology, 29, No. 8, 878–883 (2015).
Lee, M. L., Howard, M. E., Horrey, W. J., et al., “High risk of near-crash driving events following night-shift work,” Proc. Natl. Acad. Sci. USA, 113, No. 1, 176–181 (2016).
Nemoda, Z., Szekely, A., and Sasvari-Szekely, M., “Psychopathological aspects of dopaminergic gene polymorphisms in adolescence and young adulthood,” Neurosci. Biobehav. Rev., 35, No. 8, 1665–1686 (2011).
Neufang, S., Geiger, M. J., Homola, G. A., et al., “Modulation of prefrontal functioning in attention systems by NPSR1 gene variation,” Neuroimage, 114, 199–206 (2015).
Pinsonneault, J. K., Han, D. D., Burdick, K. E., et al., “Dopamine transporter gene variant affecting expression in human brain is associated with bipolar disorder,” Neuropsychopharmacology, 36, No. 8, 1644–1655 (2011).
Puchkova, A. N. and Dorokhov, V. V., “Molecular genetic studies of individual differences and professional activity,” Zh. Vyssh. Nerv. Deyat., 65, No. 2, 188–202 (2015).
Ruland, T., Domschke, K., Schlitte, V., et al., “Neuropeptide S receptor gene variation modulates anterior cingulate cortex Glx levels during CCK-4 induced panic,” Eur. Neuropsychopharmacol., 25, No. 10, 1677–1682 (2015).
Spaeth, A. M., Goel, N., and Dinges, D. F., “Managing neurobehavioral capability when social expediency trumps biological imperatives,” Prog. Brain Res., 199, 377–398 (2012).
Sullivan, D., Pinsonneault, J. K., Papp, A. C., et al., “Dopamine transporter DAT and receptor DRD2 variants affect risk of lethal cocaine abuse: a gene-gene-environment interaction,” Transl. Psychiatry, 3, e222 (2013).
Tiwari, A. K., Zai, C. C., Sajeev, G., et al., “Analysis of 34 candidate genes in bupropion and placebo remission,” Int. J. Neuropsychopharmacol., 16, No. 4, 771–781 (2013).
Wagstaff, A. S. and Sigstad Lie, J. A., “Shift and night work and long working hours – a systematic review of safety implications,” Scand. J. Work Environ. Health, 37, No. 3, 173–185 (2011).
Ziermans, T., Dumontheil, I., Roggeman, C., et al., “Working memory brain activity and capacity link MAOA polymorphism to aggressive behavior during development,” Transl. Psychiatry, 2, No. 2, e85 (2012).
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Translated from Zhurnal Vysshei Nervnoi Deyatel’nosti imeni I. P. Pavlova, Vol. 67, No. 1, pp. 49–54, January–February, 2017.
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Dorokhov, V.B., Puchkova, A.N., Taranov, A.O. et al. Gene Polymorphisms Associated with Sleep and Cognitive Functions and Their Associations with Accident Proneness in Shift-Working Bus Drivers. Neurosci Behav Physi 48, 448–452 (2018). https://doi.org/10.1007/s11055-018-0585-5
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DOI: https://doi.org/10.1007/s11055-018-0585-5