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PER1 polymorphism associated with shift work disorder

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Abstract

Workers with shift work schedules often experience shift work disorder (SWD). However, all shift workers do not necessarily develop SWD. The aim of this cross-sectional study was to investigate the association between susceptibility to SWD and clock gene polymorphisms. A total of 257 male workers from a semiconductor factory were recruited in this study. Participants completed questions about age, body mass index (BMI), shift work history, lifestyle, living conditions, the Epworth Sleepiness Scale (ESS) score, the Pittsburgh Sleep Quality Index (PSQI) score and SWD, and were genotyped with regard to the five clock gene polymorphisms. Workers were divided into two groups, namely, shift workers with SWD (n = 172) and those without SWD (n = 85). ESS and PSQI scores were significantly different between the two groups. The result of multiple logistic regression analysis showed that the PER1 G/G (OR: 0.29; 95% CI: 0.08–0.97) and C/G (OR: 0.43; 95% CI: 0.19–0.96) genotype were associated with SWD. The present study findings suggest that there is an association between the PER1 polymorphism rs3027188 and susceptibility to SWD in Japanese shift workers.

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References

  1. Drake CL, Roehrs T, Richardson G, Walsh JK, Roth T. Shift work sleep disorder: prevalence and consequences beyond that of symptomatic day workers. Sleep 2004; 27: 1453–62.

    PubMed  Google Scholar 

  2. Karlsson B, Knutsson A, Lindahl B. Is there an association between shift work and having a metabolic syndrome? Results from a population based study of 27,485 people. Occup. Environ. Med. 2001; 58: 747–52.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  3. Costa G, Haus E, Stevens R. Shift work and cancer–considerations on rationale, mechanisms, and epidemiology. Scand. J. Work Environ. Health 2010; 36: 163–79.

    Article  PubMed  Google Scholar 

  4. American Academy of Sleep Medicine. The International Classification of Sleep Disorders: Diagnostic and Coding Manual, 2nd edn. American Academy of Sleep Medicine: Westchester, 2005.

    Google Scholar 

  5. Hida A, Kitamura S, Katayose Y et al. Screening of clock gene polymorphisms demonstrates association of a PER3 polymorphism with morningness-eveningness preference and circadian rhythm sleep disorder. Sci. Rep. 2014; 4: 6309.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. Sack RL, Auckley D, Auger RR et al. Circadian rhythm sleep disorders: part I, basic principles, shift work and jet lag disorders. An American Academy of Sleep Medicine review. Sleep 2007; 30: 1460–83.

    PubMed  PubMed Central  Google Scholar 

  7. Lee H-J, Kim L, Kang S-G et al. PER2 variation is associated with diurnal preference in a Korean young population. Behav. Genet. 2011; 41: 273–7.

    Article  CAS  PubMed  Google Scholar 

  8. Archer SN, Robilliard DL, Skene DJ et al. A length polymorphism in the circadian clock gene Per3 is linked to delayed sleep phase syndrome and extreme diurnal preference. Sleep 2003; 26: 413–15.

    PubMed  Google Scholar 

  9. Ebisawa T, Uchiyama M, Kajimura N et al. Association of structural polymorphisms in the human period3 gene with delayed sleep phase syndrome. EMBO Rep. 2001; 2: 342–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Toh KL, Jones CR, He Y et al. An hPer2 phosphorylation site mutation in familial advanced sleep phase syndrome. Science 2001; 291: 1040–3.

    Article  CAS  PubMed  Google Scholar 

  11. Waage S, Moen BE, Pallesen S et al. Shift work disorder among oil rig workers in the North Sea. Sleep 2009; 32: 558–65.

    PubMed  PubMed Central  Google Scholar 

  12. Flo E, Pallesen S, Magerøy N et al. Shift work disorder in nurses–assessment, prevalence and related health problems. PLoS ONE 2012; 7: e33981.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Doi Y, Minowa M, Uchiyama M. Development of the Japanese version of the Pittsburgh Sleep Quality Index. Seishinka Chiryougaku 1998; 13: 755–63. (In Japanese.)

    Google Scholar 

  14. Takegami M, Suzukamo Y, Wakita T et al. Development of a Japanese version of the Epworth Sleepiness Scale (JESS) based on item response theory. Sleep Med. 2009; 10: 556–65.

    Article  PubMed  Google Scholar 

  15. Grundy Al, Schuetz JM, Lai AS et al. Shift work, circadian gene variants and risk of breast cancer. Cancer Epidemiol. 2013; 37: 606–12.

    Article  CAS  PubMed  Google Scholar 

  16. Zhu Y, Stevens RG, Hoffman AE et al. Testing the circadian gene hypothesis in prostate cancer: a population-based case-control study. Cancer Res. 2009; 69: 9315–22.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Reppert SM, Weaver DR. Coordination of circadian timing in mammals. Nature 2002; 418: 935–41.

    Article  CAS  PubMed  Google Scholar 

  18. Walton KM, Fisher K, Rubitski D et al. Selective inhibition of casein kinase 1 epsilon minimally alters circadian clock period. J. Pharmacol. Exp. Ther. 2009; 330: 430–9.

    Article  CAS  PubMed  Google Scholar 

  19. Franken P, Dijk DJ. Circadian clock genes and sleep homeostasis. Eur. J. Neurosci. 2009; 29: 1820–9.

    Article  CAS  PubMed  Google Scholar 

  20. Gamble KL, Motsinger-Reif AA, Hida A et al. Shift work in nurses: contribution of phenotypes and genotypes to adaptation. PLoS ONE 2011; 6: e18395.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  21. Viola AU, Archer SN, James LM et al. PER3 polymorphism predicts sleep structure and waking performance. Curr. Biol. 2007; 17: 613–18.

    Article  CAS  PubMed  Google Scholar 

  22. Reszka E, Peplonska B, Wieczorek E et al. Rotating night shift work and polymorphism of genes important for the regulation of circadian rhythm. Scand. J. Work Environ. Health 2013; 39: 178–86.

    Article  CAS  PubMed  Google Scholar 

  23. Partonen T. Clock gene variants in mood and anxiety disorders. J. Neural Transm. 2012; 119: 1133–45.

    Article  CAS  PubMed  Google Scholar 

  24. Barbosa AA, Pedrazzoli M, Koike BD, Tufik S. Do Caucasian and Asian clocks tick differently? Braz. J. Med. Biol. Res. 2010; 43: 96–9.

    Article  CAS  PubMed  Google Scholar 

  25. Birney E, Lieb JD, Furey TS, Crawford GE, Iyer VR. Allele-specific and heritable chromatin signatures in humans. Hum. Mol. Genet. 2010; 19: 204–9.

    Article  Google Scholar 

  26. Cheung VG, Spielman RS. Genetics of human gene expression: mapping DNA variants that influence gene expression. Nat. Rev. Genet. 2009; 10: 595–604.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  27. Berulava T, Horsthemke B. The obesity-associated SNPs in intron 1 of the FTO gene affect primary transcript levels. Eur. J. Hum. Genet. 2010; 18: 1054–6.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  28. Khan SG, Muniz-Medina V, Shahlavi T et al. The human XPC DNA repair gene: arrangement, splice site information content and influence of a single nucleotide polymorphism in a splice acceptor site on alternative splicing and function. Nucleic Acids Res. 2002; 30: 3624–31.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  29. Liu Z, Huang M, Wu X et al. PER1 phosphorylation specifies feeding rhythm in mice. Cell Rep. 2014; 7: 1509–20.

    Article  CAS  PubMed  Google Scholar 

  30. Richards J, All S, Skopis G et al. Opposing actions of Per1 and Cry2 in the regulation of Per1 target gene expression in the liver and kidney. Am. J. Physiol. Regul. Integr. Comp. Physiol. 2013; 305: R735–47.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Asaoka S, Aritake S, Komada Y et al. Factors associated with shift work disorder in nurses working with rapidrotation schedules in Japan: the nurses’ sleep health project. Chronobiol. Int. 2013; 30: 628–36.

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Department of Public Health, Faculty of Medicine, University of Miyazaki, 5200 Kiyotakecho Kihara, Miyazaki-city, 889-1692, Japan

    Yukari Taniyama, Takenori Yamauchi, Shouhei Takeuchi & Yoshiki Kuroda

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  1. Yukari Taniyama
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  2. Takenori Yamauchi
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  3. Shouhei Takeuchi
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  4. Yoshiki Kuroda
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Correspondence to Yukari Taniyama.

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Taniyama, Y., Yamauchi, T., Takeuchi, S. et al. PER1 polymorphism associated with shift work disorder. Sleep Biol. Rhythms 13, 342–347 (2015). https://doi.org/10.1111/sbr.12123

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