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Involvement of the Distal Fragment of Chromosome 13 in the Regulation of Sensitivity to Ethanol in Mice

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The role of mouse chromosome 13 fragment 57-65 cM in regulating the actions of ethanol on motor activity, anxiety, and sensitivity to the hypnotic and hypothermic effects of ethanol was studied. Male AKR/J mice and recombinant strain AKR.CBA-D13Mit76C, which differ only in terms of this fragment, were used. After acute administration of ethanol, only AKR mice showed an increase in trajectory length in the open field test (p < 0.05), while only AKR.CBA-D13Mit76C mice showed an increase in the time taken to find the center of the open field arena (p < 0.05). There were no differences in sleep duration or the intensity of hypothermia induced by injections of large doses of ethanol in intact animals of both strains. At the same time, prolonged alcoholization led to weakening of the hypnotic effect of ethanol in males of both strains as compared with intact animals (p < 0.01 for AKR, p < 0.001 for AKR.CBA-D13Mit76C). Chronic alcoholization led to an increase in ethanol-induced hypothermia in AKR males as compared with intact animals (p < 0.01) but had no effect on the severity of the hypothermic effect of ethanol in AKR.CBA-D13Mit76C mice. These results provide evidence that the distal fragment 57-65 cM of chromosome 13 has a role in the mechanisms of action of ethanol in mice.

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Authors and Affiliations

  1. Institute of Cytology and Genetics, Siberian Branch, Russian Academy of Sciences, Novosibirsk, Russia

    D. V. Bazovkina & A. V. Kulikov

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  1. D. V. Bazovkina
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  2. A. V. Kulikov
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Correspondence to D. V. Bazovkina.

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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 101, No. 1, pp. 25–34, January, 2015.

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Bazovkina, D.V., Kulikov, A.V. Involvement of the Distal Fragment of Chromosome 13 in the Regulation of Sensitivity to Ethanol in Mice. Neurosci Behav Physi 46, 566–570 (2016). https://doi.org/10.1007/s11055-016-0278-x

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