The aim of the present work was to compare the effects of stimulation and blockade of D2 dopamine receptors on depression-like behavior in male rats in conditions of androgen deficiency. The D2 dopamine receptor agonist quinpirole (0.1 mg/kg, i.p.) and the D2 dopamine receptor antagonist sulpiride (10.0 mg/kg, i.p.) were given daily for 14 days both alone and in combination with low-dose testosterone propionate (0.5 mg/kg, s.c.) to gonadectomized (GE) males. Dopaminergic substances were given before behavioral testing and then throughout the test period. Depression-like behavior was assessed using the Porsolt test, while the nature of orientational-exploratory behavior was evaluated using the open field test. Chronic administration of sulpiride to GE males did not produce any significant change to the extent of depression-like behavior in the Porsolt test as compared with the control group (p > 0.05). However, combined administration of sulpiride and low-dose testosterone propionate to GE males led to a prodepressant effect as compared with controls (p < 0.05). In the open field test, this group of rats showed increases in grooming and exploratory activity from the levels seen in controls (p < 0.05). Use of quinpirole or its combination with low-dose testosterone propionate produced a marked antidepressant effect in the Porsolt test (p < 0.05) as compared with the control groups and GE males given testosterone propionate only. The combination of quinpirole and testosterone propionate produced positive effects which were the sum of the individual effects of the two substances alone on the level of depressivity in the Porsolt test. Administration of quinpirole alone or in combination with low-dose testosterone propionate did not alter total movement activity but increased the proportion of grooming in GE males from the control level. The results obtained here provide evidence that stimulation of D2 dopamine receptors leads to antidepressant actions in androgen-deficient male rats while blockade of D2 dopamine receptors, conversely, has a prodepressant effect.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 100, No. 12, pp. 1374–1381, December, 2014.
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Fedotova, Y.O. Effects of Stimulation and Blockade of D2 Dopamine Receptors on the Behavior of Gonadectomized Male Rats. Neurosci Behav Physi 46, 544–547 (2016). https://doi.org/10.1007/s11055-016-0274-1
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DOI: https://doi.org/10.1007/s11055-016-0274-1