The development of a depression-like state in C57BL/6 J mice is accompanied by significant reductions in immune responses. Administration of the selective agonist of 5-HT1A receptors 8-OH-DPAT to these animals at doses affecting both presynaptic receptors (0.1 mg/kg) and postsynaptic receptors (1.0 mg/kg) did not alter the number of IgM antibody-forming cells (AFC) in the spleen at the peak of the immune response, i.e., day 4 after administration of sheep erythrocytes, in mice with depression-like behavior. At the same time, activation of presynaptic 5-HT1A receptors in control mice (without experience of victory or defeat) induced increases in the immune response, while stimulation of postsynaptic receptors led to immunosuppression. The question of decreases in the sensitivity of pre- and postsynaptic 5-HT1A receptors during formation of depression-like behavior and the role of the functional activity of this type of receptor in the development of the immune responses in these conditions is discussed.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 96, No. 11, pp. 1097–1102, November, 2010.
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Idova, G.V., Yuriev, D.V. & Kuznetsova, S.M. Immune Responses on Activation of Pre- and Postsynaptic Serotonin 5-HT1A Receptors in Mice with Depression-Like States. Neurosci Behav Physi 42, 308–311 (2012). https://doi.org/10.1007/s11055-012-9567-1
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DOI: https://doi.org/10.1007/s11055-012-9567-1