The phenomenon of latent inhibition is used in studies of the processes of selective attention in the context of reinforcement training. The aim of the present work was to compare the ability of hypertensive ISIAH and normotensive parental-strain Wistar rats, which have different psychoemotional states, to ignore irrelevant stimuli. Latent inhibition was formed in conditions of passive and active avoidance reactions, whose acquisition was preceded by repeated presentation (pre-exposure) of stimuli without reinforcement. ISIAH rats showed impairment to latent inhibition in both behavioral tasks as compared with Wistar rats. These data provide grounds for suggesting that the deficit in selecting information in ISIAH rats is due to an innate weakness of the processes of internal inhibition in conditions of adaptation to anxiogenic stimuli.
This is a preview of subscription content, log in via an institution to check access.
Similar content being viewed by others
References
L. V. Loskutova and L. M. Zelenkina, “Impairments to latent inhibition in OXYS rats with genetically determined premature aging syndrome,” Zh. Vyssh. Nerv. Deyat., 52, No. 3, 366–370 (2002).
L. V. Loskutova, N. I. Dubrovina, and A. L. Markel, “Comparative analysis of the persistence of a conditioned passive avoidance reaction in rats with different types of inherited arterial hypertension,” Ros. Fiziol. Zh. im. I. M. Sechenova, 92, No. 4, 440–448 (2006).
L. V. Loskutova, A. V. Filaretov, N. I. Dubrovina, and A. L. Markel, “Characteristics of the acquisition of a conditioned active avoidance reaction in rats with different types of inherited arterial hypertension,” Byull. Eksperim. Biol. Med., 142, No. 10, 386–388 (2006).
L. N. Maslova, B. B. Bulygina, and N. K. Popova, “Characteristics of the acoustic startle reflex in rats with inherited stress-sensitive arterial hypertension,” Zh. Vyssh. Nerv. Deyat., 49, No. 4, 645–651 (1999).
L. N. Maslova and V. V. Bulygina, “Chronic stress in the prepubertal period and the formation of psychoemotional status in rats,” Zh. Vyssh. Nerv. Deyat., 52, No. 1, 86–92 (2002).
Yu. V. Khvorostova, E. V. Kalashnikova, O. P. Cherkasova, L. A. Fedoseeva, O. E. Redina, G. M. Dymshits, and A. L. Markel, “Characteristics of the expression of the glucocorticoid receptor gene in hypertensive ISIAH rats,” Ros. Fiziol. Zh. im. I. M. Sechenova, 89, No. 12, 1523–1528 (2003).
H. Braunstein-Bercovitz, I. Dimentman-Askhenazi, and R. E. Lubow, “Stress affects the selection of relevant from irrelevant stimuli,” Emotion, 1, 182–192 (2001).
Y. Ida, A. Tsuda, K. Sueyoshi, I. Shirao, and M. Tanaka, “Blockade by diazepam of conditioned fear-induced activation of rat mesoprefrontal dopamine neurons,” Pharmacol. Biochem. Behav., 33, 477–479 (1989).
R. E. Lubow, “Construct validity of the animal latent inhibition model of selective attention deficits in schizophrenia,” Schizophr. Bull., 31, 139–153 (2005).
M. L. Phillips,W. S. Drevets, S. L. Rauch, and R. Lane, “Neurobiology of emotion perception II: Implications for major psychiatric disorders,” Biol. Psychiatry, 54, 515–528 (2003).
P. Singer, J. Feldon, and B. Yee, “Are DBA/2 mice associated with schizophrenia-like endophenotypes? A behavioral contrast with C57BL/6 mice,” Psychopharmacology (Berlin), 206, No. 4, 677–698 (2009).
I. Weiner, “The ‘two-headed’ latent inhibition model of schizophrenia: modeling positive and negative symptoms and their treatment,” Psychopharmacology, 169, 257–297 (2003).
Author information
Authors and Affiliations
Corresponding author
Additional information
Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 96, No. 10, pp. 966–971, October, 2010.
Rights and permissions
About this article
Cite this article
Loskutova, L.V., Kostyunina, N.V. Impairments to Latent Inhibition in ISIAH Rats, with Inherited Stress-Induced Arterial Hypertension. Neurosci Behav Physi 42, 253–256 (2012). https://doi.org/10.1007/s11055-012-9560-8
Received:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s11055-012-9560-8