The relationship between changes in the phospholipid composition of the frontal lobes of the cerebral cortex and stress resistance was studied in white mongrel male rats initially tested in an open field test. Immobilization stress (daily 2-hr periods of immobilization) for 5, 10, 15, 20, 30, and 45 days produced significant depletion of prefrontal cortex phospholipids, with differences in their metabolism in stressresistant and stress-susceptible animals. The results obtained here suggest a criterion for individual stress resistance which may be of interest for developing methods of increasing resistance to extreme situations by correcting the biogenesis of nerve cells.
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Translated from Rossiiskii Fiziologicheskii Zhurnal imeni I. M. Sechenova, Vol. 95, No. 8, pp. 830–836, August, 2009.
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Tsygvintsev, A.A., Bryndina, I.G. Influence of Stress Resistance on Changes in the Phospholipid Composition of the Prefrontal Cortex of the Brain in Rats in Immobilization Stress. Neurosci Behav Physi 40, 993–997 (2010). https://doi.org/10.1007/s11055-010-9358-5
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DOI: https://doi.org/10.1007/s11055-010-9358-5