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Engineering micro/nano-fibrous scaffolds with silver coating for tailored wound repair applications

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Abstract

Electrospun scaffolds originating from polymeric amalgams, specifically poly(glycerol sebacate/poly(ε-caprolactone) (PGS/PCL) and poly(methyl methacrylate)–poly(ε-caprolactone) (PMMA/PCL), have emerged as a versatile substrate within the realm of biomedical tissue engineering. Their salience is underscored by their remarkable thermal, optical, and mechanical attributes. In this investigation, we harnessed conventional electro-spinning methodologies to fabricate nano/micro-fibrous scaffolds from a hybrid composite, amalgamating PMMA/PCL and PGS/PCL fibers. A pivotal innovation lay in the precise deposition of silver nanoparticles (AgNPs) on one facet of these scaffolds, endowing them with anti-bacterial functionality. This AgNP coating not only forestalled melting proclivities but also meticulously tuned structural facets, engendering a diminution in pore diameter and augmentation in fiber diameter, thereby engendering an elevation in thermo-mechanical performance. Comparative scrutiny delineated that the PMMA/PCL composite fibrous scaffolds manifested superior mechanical attributes, including augmented modulus (E) and ultimate tensile strength (UTS), accompanied by attenuated tensile strain, obviating the requisite for supplementary post-processing steps. These AgNP-endowed composite fibrous scaffolds engender sanguine prospects for biomedical applications, encompassing surgical meshes, bandages, and band-aids, underpinned by their amplified anti-bacterial characteristics, which are instrumental in the context of wound healing.

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Acknowledgements

The authors would like to thank the Government City College (A), Osmania University, Hyderabad for utilizing facilities.

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Authors and Affiliations

  1. Department of Physics, Government City UG/PG College (A), Nayapul, Osmania University, Hyderabad, 500002, Telangana, India

    Parvathalu Kalakonda, Shalini Thudumu, Soujanya Laxmi Mynepally & Bala Bhaskar Podili

  2. Department of Physics, Michigan Technological University, Houghton, MI, 4993, USA

    Pritam Mandal

  3. Department of Chemistry and Biosciences, Rice University-BRC, Houston, TX, 77005, USA

    Sreenivas Banne

  4. Department of Materials Science and Engineering, North Carolina State University, Raleigh, NC, 27695, USA

    Pranay Bhaskar Kalakonda

Authors
  1. Parvathalu Kalakonda
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  2. Shalini Thudumu
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  3. Soujanya Laxmi Mynepally
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  4. Pritam Mandal
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  5. Sreenivas Banne
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  6. Pranay Bhaskar Kalakonda
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  7. Bala Bhaskar Podili
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Contributions

Parvathalu Kalakonda: supervision and execution, writing—original draft and editing, and visualization. Shalini Thudumu and Sowjanya Laxmi: designing experiment and data collection. All the other authors were involved in various parts of discussion of the project.

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Correspondence to Parvathalu Kalakonda.

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Kalakonda, P., Thudumu, S., Mynepally, S. . et al. Engineering micro/nano-fibrous scaffolds with silver coating for tailored wound repair applications. J Nanopart Res 25, 254 (2023). https://doi.org/10.1007/s11051-023-05903-2

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