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Manganese oxide nanoparticles: the influence of manganese oxidation state on selective lysis of tumor cells

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Abstract

Further studies on the mechanism of intracellular induction of active oxygen species and selective oncolysis with metal oxide nanoparticles (NPs), as well as the discussion of alternative mechanisms of the NPs impact on tumor cells, are needed to introduce nanotechnologies into antitumor therapy. The paper concerns the inhibition of oxidation processes in tumor cells under the action of manganese oxide-based NPs (size 10–60 nm) as the mechanism of a tumor cell death. When manganese (II) hydroxide-based NPs enter the cells, they are oxidized with oxygen to Mn4+ compounds; the oxidation processes being blocked in the tumor cells. Hence, the MnO NPs cytotoxicity can be due to the possible direct reduction of O2 in the presence of manganese compounds in the cells.

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Acknowledgements

HRTEM and SEM studies were conducted under the 0303-2017-0002 AAAA-A17-117041710079-8 (Unit 3) project at the Boreskov Institute of Catalysis.

Funding

The studies were supported by the budget project (No. FWNR-2022-0023) and implemented using the facilities of the Center for Genetic Resources of Laboratory Animals at ICG SB RAS, supported by the Ministry of Education and Science of Russia (RFMEFI62119X0023).

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Authors and Affiliations

  1. Federal Research Center Institute of Cytology and Genetics, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia

    Ivan Razumov & Olga Solovieva

  2. Novosibirsk State University, Novosibirsk, 630090, Russia

    Ivan Razumov & Olga Solovieva

  3. Federal Research Center Boreskov Institute of Catalysis, Siberian Branch of the Russian Academy of Sciences, Novosibirsk, 630090, Russia

    Sergei Troitskii & Evgenii Suprun

Authors
  1. Ivan Razumov
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  2. Sergei Troitskii
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  3. Olga Solovieva
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  4. Evgenii Suprun
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Contributions

All authors contributed to the study’s conception and design. Material preparation, data collection, and analysis were performed by Ivan Razumov, Sergei Troitskii, and Olga Solovieva. Evgenii Suprun conducted microscopic studies and analysis of the obtained data. The first draft of the manuscript was written by Ivan Razumov. All authors commented on previous versions of the manuscript. All authors had read and approved the final manuscript.

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Correspondence to Olga Solovieva.

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Razumov, I., Troitskii, S., Solovieva, O. et al. Manganese oxide nanoparticles: the influence of manganese oxidation state on selective lysis of tumor cells. J Nanopart Res 25, 140 (2023). https://doi.org/10.1007/s11051-023-05782-7

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  • DOI: https://doi.org/10.1007/s11051-023-05782-7

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