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Nanostructured mesoporous silica: new perspectives for fighting antimicrobial resistance

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Abstract

This paper investigates the antimicrobial potential of nanostructured mesoporous silica (NMS) functionalized with essential oils (EOs) and antibiotics (ATBs). The NMS networks were obtained by the basic procedure from cetyltrimethylammonium bromide and tetraethyl orthosilicate in the form of granules with diameters ranging from 100 to 300 nm with an average pore diameter of 2.2 nm, as confirmed by the BET–TEM analyses. The Salvia officinalis (SO) and Coriandrum sativum (CS) EOs and the streptomycin and neomycin ATBs were loaded in the NMS pores. TG analysis was performed in order to estimate the amount of the entrapped volatile EOs. The results of the biological analyses revealed that NMS/SO and NMS/CS exhibited a very good antimicrobial activity to an extent comparable or even superior to the one triggered by ATB, and a good in vitro and in vivo biocompatibility. Due to their regular pores, high biocompatibility, antimicrobial activity, and capacity to stabilize the volatile EOs, the obtained NMS can be used as an efficient drug delivery system for further biomedical applications.

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Acknowledgments

This research was financially supported by Sectoral Operational Programme Human Resources Development, financed from the European Social Fund and by the Romanian Government under the contract number POSDRU/156/1.2/G/135764. Improvement and implementation of university master programs in the field of Applied Chemistry and Materials Science-ChimMaster.

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Authors and Affiliations

  1. Department of Science and Engineering of Oxide Materials and Nanomaterials, Faculty of Applied Chemistry and Materials Science, Politehnica University of Bucharest, Polizu Street No 1-7, 011061, Bucharest, Romania

    Georgeta Voicu, Ionuţ Dogaru, Daniela Meliţă, Raluca Meştercă, Vera Spirescu, Eliza Stan, Eliza Tote, Alexandru Mihai Grumezescu, Eugeniu Vasile & Alina Maria Holban

  2. Department of Biomaterials and Medical Devices, Faculty of Medical Engineering, University Politehnica of Bucharest, Polizu Street, No 1-7, 011061, Bucharest, Romania

    Ionuţ Dogaru, Daniela Meliţă, Raluca Meştercă, Vera Spirescu, Eliza Stan, Eliza Tote & Alexandru Mihai Grumezescu

  3. Research Center for Microscopic Morphology and Immunology, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349, Craiova, Romania

    Laurenţiu Mogoantă

  4. Department of Pharmacognosy & Phytotherapy, Faculty of Pharmacy, University of Medicine and Pharmacy of Craiova, 2 Petru Rareş Street, 200349, Craiova, Romania

    George Dan Mogoşanu

  5. Metav SA-CD S.A., 31 Rosetti Street, 020015, Bucharest, Romania

    Roxana Truşcă

  6. Department of Fetal and Adult Stem Cell Therapy, Institute of Cellular Biology and Pathology of Romanian Academy, “Nicolae Simionescu”, 8, B.P. Hasdeu, 050568, Bucharest, Romania

    Florin Iordache

  7. Microbiology Department, Faculty of Biology, University of Bucharest, Aleea Portocalelor No 1-3, 060101, Bucharest, Romania

    Mariana-Carmen Chifiriuc & Alina Maria Holban

  8. Life, Environment and Earth Sciences Section, Research Institute of the University of Bucharest-ICUB, Spl. Independentei 91-95, Bucharest, Romania

    Mariana-Carmen Chifiriuc

Authors
  1. Georgeta Voicu
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  2. Ionuţ Dogaru
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  3. Daniela Meliţă
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  4. Raluca Meştercă
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  5. Vera Spirescu
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  6. Eliza Stan
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  7. Eliza Tote
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  8. Laurenţiu Mogoantă
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  9. George Dan Mogoşanu
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  10. Alexandru Mihai Grumezescu
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  11. Roxana Truşcă
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  12. Eugeniu Vasile
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  13. Florin Iordache
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  14. Mariana-Carmen Chifiriuc
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  15. Alina Maria Holban
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Corresponding author

Correspondence to Alexandru Mihai Grumezescu.

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Voicu, G., Dogaru, I., Meliţă, D. et al. Nanostructured mesoporous silica: new perspectives for fighting antimicrobial resistance. J Nanopart Res 17, 201 (2015). https://doi.org/10.1007/s11051-015-3004-7

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  • DOI: https://doi.org/10.1007/s11051-015-3004-7

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