Abstract
Hydroxyapatite (HAp) ceramics are widely used as artificial bone substitutes owing to its unique biological activity, that is, bone-bonding property. HAp nanoparticles have higher potential of biological functionality than microparticles owing to their increased specific surface area (SSA) because biological functionality of the crystals is governed by their surface characteristics. HAp particles of varied size and morphology have been prepared by employing various kinds of surfactants and capping ligands. In this research, we report the formation of HAp nanorods with serrated morphology which led to an increase in SSA. We obtained HAp nanorods with serrated morphology by adding thiosalicylic acid as a capping ligand under hydrothermal conditions. The tailoring of HAp nanorods by thiosalicylic acid under hydrothermal conditions is a useful method to prepare HAp nanorods with improved functionality.
Similar content being viewed by others
References
Anselme K, Davidson P, Popa AM, Giazzon M, Liley M, Ploux L (2010) The interaction of cells and bacteria with surfaces structured at the nanometre scale. Acta Biomater 6(10):3824–3846. doi:10.1016/j.actbio.2010.04.001
Cheng ZH, Yasukawa A, Kandori K, Ishikawa T (1998) FTIR study of adsorption of CO2 on nonstoichiometric calcium hydroxyapatite. Langmuir 14(23):6681–6686. doi:10.1021/la980339n
Colfen H (2007) Bio-inspired mineralization using hydrophilic polymers. In: Naka K (ed) Biomineralization II: mineralization using synthetic polymers and templates. Topics in current chemistry, vol 271, 1st edn. Springer-Verlag, Berlin, pp 1–77. doi:10.1007/128_056
Eichert D, Drouet C, Sfihia H, Rey C, Combes C (2009) Nanocrystalline apatite-based biomaterials. Nova Science Publishers, Inc., New York
Elliot JC (1994) Structure and chemistry of the apatites and other calcium orthophosphates. Elsevier, Amsterdam
Gao Y, Tang ZY (2011) Design and application of inorganic nanoparticle superstructures: current status and future challenges. Small 7(15):2133–2146. doi:10.1002/smll.201100474
Gong J, Li G, Tang Z (2012) Self-assembly of noble metal nanocrystals: fabrication, optical property, and application. Nano Today 7(6):564–585. doi:10.1016/j.nantod.2012.10.008
Hui JF, Xiang GL, Xu XX, Zhuang J, Wang X (2009) Monodisperse F-substituted hydroxyapatite single-crystal nanotubes with amphiphilic surface properties. Inorg Chem 48(13):5614–5616. doi:10.1021/ic900697b
Kalita SJ, Bhardwaj A, Bhatt HA (2007) Nanocrystalline calcium phosphate ceramics in biomedical engineering. Mater Sci Eng C 27(3):441–449. doi:10.1016/j.msec.2006.05.018
Kuchibhatla S, Karakoti AS, Bera D, Seal S (2007) One dimensional nanostructured materials. Prog Mater Sci 52(5):699–913. doi:10.1016/j.pmatsci.2006.08.001
Olszta MJ, Cheng XG, Jee SS, Kumar R, Kim YY, Kaufman MJ, Douglas EP, Gower LB (2007) Bone structure and formation: a new perspective. Mat Sci Eng R 58(3–5):77–116. doi:10.1016/j.mser.2007.05.001
Shi ZL, Huang X, Cai YR, Tang RK, Yang DS (2009) Size effect of hydroxyapatite nanoparticles on proliferation and apoptosis of osteoblast-like cells. Acta Biomater 5(1):338–345. doi:10.1016/j.actbio.2008.07.023
Smith B (1998) Infrared spectral interpretation: a systematic approach. CRC Press, New York
Suchanek W, Yoshimura M (1998) Processing and properties of hydroxyapatite-based biomaterials for use as hard tissue replacement implants. J Mater Res 13(1):94–117. doi:10.1557/jmr.1998.0015
Tan YW, Wang Y, Jiang L, Zhu DB (2002) Thiosalicylic acid-functionalized silver nanoparticles synthesized in one-phase system. J Colloid Interface Sci 249(2):336–345. doi:10.1006/jcis.2001.8166
Tang ZY, Kotov NA, Giersig M (2002) Spontaneous organization of single CdTe nanoparticles into luminescent nanowires. Science 297(5579):237–240. doi:10.1126/science.1072086
Tang ZY, Wang Y, Podsiadlo P, Kotov NA (2006) Biomedical applications of layer-by-layer assembly: from biomimetics to tissue engineering. Adv Mater 18(24):3203–3224. doi:10.1002/adma.200600113
Xia YS, Nguyen TD, Yang M, Lee B, Santos A, Podsiadlo P, Tang ZY, Glotzer SC, Kotov NA (2011) Self-assembly of self-limiting monodisperse supraparticles from polydisperse nanoparticles. Nat Nanotechnol 6(9):580–587. doi:10.1038/nnano.2011.121
Yoshimura M, Byrappa K (2008) Hydrothermal processing of materials: past, present and future. J Mater Sci 43(7):2085–2103. doi:10.1007/s10853-007-1853-x
Zhang CM, Yang J, Quan ZW, Yang PP, Li CX, Hou ZY, Lin J (2009) Hydroxyapatite nano- and microcrystals with multiform morphologies: controllable synthesis and luminescence properties. Cryst Growth Des 9(6):2725–2733. doi:10.1021/cg801353n
Zhou H, Lee J (2011) Nanoscale hydroxyapatite particles for bone tissue engineering. Acta Biomater 7(7):2769–2781. doi:10.1016/j.actbio.2011.03.019
Acknowledgments
S. Prakash Parthiban thanks the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan, for the award of Japanese Government Scholarship through the Ministry of Human Resource Development (MHRD), India. This work was partially supported by a Grant-in-Aid for Scientific Research (No. 22107007) on the Innovative Areas: “Fusion Materials” (Area no. 2206) from the Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan.
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Prakash Parthiban, S., Kim, I.Y., Kikuta, K. et al. Formation of serrated nanorods of hydroxyapatite through organic modification under hydrothermal processing. J Nanopart Res 15, 1657 (2013). https://doi.org/10.1007/s11051-013-1657-7
Received:
Accepted:
Published:
DOI: https://doi.org/10.1007/s11051-013-1657-7