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Nanoengineering of methylene blue loaded silica encapsulated magnetite nanospheres and nanocapsules for photodynamic therapy

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Abstract

Core–shell nanostructures have emerged as an important class of functional materials with potential applications in diverse fields, especially in health sciences. In this article, nanoengineering of novel magnetic colloidal dispersion containing surface modifiable silica with a core of single domain magnetite nanoparticles loaded with photosensitizer (PS) drug “Methylene blue” (MB) has been described. Magnetite core is produced by the well-established chemical coprecipitation technique and silica shell is formed over it by the modified hydrolysis and condensation of TEOS (tetraethyl orthosilicate). Conditions for reaction kinetics have been established to tailor the core–shell structures in the form of nanospheres and nanocapsules. MB is loaded into the nanostructures by demethylation reaction. The major conclusion drawn from this study is that the synthesis route yields stable, non-aggregated MB loaded superparamagnetic magnetite-silica nanostructures with tailored morphology, tunable loading, and excellent magnetic properties.

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Authors and Affiliations

  1. Department of Physics, Bhavnagar University, Bhavnagar, 364022, India

    Nidhi Andhariya & R. V. Mehta

  2. School of Physics and Materials Science, Thapar University, Patiala, 147004, India

    Bhupendra Chudasama

  3. P.D. Patel Institute of Applied Sciences, Charotar University of Science and Technology, Education Campus, Changa, 388421, India

    R. V. Upadhyay

Authors
  1. Nidhi Andhariya
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  2. Bhupendra Chudasama
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  3. R. V. Mehta
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  4. R. V. Upadhyay
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Correspondence to Bhupendra Chudasama.

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Andhariya, N., Chudasama, B., Mehta, R.V. et al. Nanoengineering of methylene blue loaded silica encapsulated magnetite nanospheres and nanocapsules for photodynamic therapy. J Nanopart Res 13, 3619–3631 (2011). https://doi.org/10.1007/s11051-011-0279-1

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  • DOI: https://doi.org/10.1007/s11051-011-0279-1

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