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Disseminated Mucormycosis Due to Saksenaea vasiformis Complex in an Immunocompetent Adult with Sustained Response to Posaconazole Treatment

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Abstract

Saksenaea vasiformis complex is an emerging cause of mucormycosis. We report a case of an immunocompetent patient presenting with a non-resolving lung mass who developed multiple skin nodules. Skin biopsy yielded Saksenaea vasiformis complex. This showcases an uncommon occurrence of disseminated Saksenaea infection without cutaneous inoculation that improved with posaconazole.

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References

  1. Gomes MZ, Lewis RE, Kontoyiannis DP. Mucormycosis caused by unusual mucormycetes, non-Rhizopus, -Mucor, and -Lichtheimia species. Clin Microbiol Rev. 2011;24(2):411–45. https://doi.org/10.1128/CMR.00056-10.

    Article  PubMed  PubMed Central  Google Scholar 

  2. Samaras K, Markantonatou AM, Karapiperis D, Digonis P, Kartalis N, Kostogloudis N, Vyzantiadis TA. Saksenaea vasiformis infections: a case of an immunocompetent adult after mild injury and a literature review. J Mycol Med. 2019;29(3):260–4. https://doi.org/10.1016/j.mycmed.2019.06.005.

    Article  CAS  PubMed  Google Scholar 

  3. Solano T, Atkins B, Tambosis E, Mann S, Gottlieb T. Disseminated mucormycosis due to Saksenaea vasiformis in an immunocompetent adult. Clin Infect Dis. 2000;30:942–3.

    Article  CAS  Google Scholar 

  4. Garcia-Hermoso D, Hoinard D, Gantier J-C, Grenouillet F, Dromer F, Dannaoui E. Molecular and phenotypic evaluation of Lichtheimia corymbifera (Formerly Absidia corymbifera) complex isolates associated with human mucormycosis: rehabilitation of L. ramosa. J. Clin. Microbiol. 2009;47(12):3862–70.

    Article  CAS  Google Scholar 

  5. Ribes JA, Vanover-Sams CL, Baker DJ. Zygomycetes in human disease. Clin Microbiol Rev. 2000;13:236–301.

    Article  CAS  Google Scholar 

  6. Dellière S, Rivero-Menendez O, Gautier C, Garcia-Hermoso D, Alastrey-Izquierdo A, Alanio A. Emerging mould infections: get prepared to meet unexpected fungi in your patient. Med Mycol. 2019. https://doi.org/10.1093/mmy/myz039.

    Article  Google Scholar 

  7. Torell J, Cooper BH, Helgeson NG. Disseminated Saksenaea vasiformis infection. Am J Clin Pathol. 1981;76:116–21.

    Article  CAS  Google Scholar 

  8. Hay RJ, Campbell CK, Marshall WM, et al. Disseminated zygomycosis (mucormycosis) caused by Saksenaea vasiformis. J Infect. 1983;7:162–5.

    Article  CAS  Google Scholar 

  9. Trotter DJ, Gonis G, Cottrill E, Coombs C. Disseminated Saksenaea vasiformis in an immunocompetent host. Med J Aust. 2008;189(9):519–20.

    Article  Google Scholar 

  10. Gómez-Camarasa C, Rojo-Martín MD, Miranda-Casas C, Alastruey-Izquierdo A, Aliaga-Martínez L, Labrador-Molina JM, Navarro-Marí JM. Disseminated infection due to Saksenaea vasiformis secondary to cutaneous mucormycosis. Mycopathologia. 2014;177(1–2):97–101. https://doi.org/10.1007/s11046-013-9715-3.

    Article  PubMed  Google Scholar 

  11. Kaushik R, Chander J, Gupta S, Sharma R, Punia RS. Fatal primary cutaneous zygomycosis caused by Saksenaea vasiformis: case report and review of literature. Surg Infect (Larchmt). 2012;13(2):125–9. https://doi.org/10.1089/sur.2010.078.

    Article  Google Scholar 

  12. Chander J, Singla N, Kaur M, Punia RS, Attri A, Alastruey-Izquierdo A, Cano-Lira JF, Stchigel AM, Guarro J. Saksenaea erythrospora, an emerging mucoralean fungus causing severe necrotizing skin and soft tissue infections—a study from a tertiary care hospital in north India. Infect Dis (Lond). 2017;49(3):170–7. https://doi.org/10.1080/23744235.2016.1239027.

    Article  Google Scholar 

  13. Gkegkes ID, Kotrogiannis I, Konstantara F, Karetsou A, Tsiplakou S, Fotiou E, Stamopoulou S, Papazacharias C, Paraskevopoulos IA. Cutaneous mucormycosis by Saksenaea vasiformis: an unusual case report and review of literature. Mycopathologia. 2019;184(1):159–67. https://doi.org/10.1007/s11046-018-0249-6.

    Article  PubMed  Google Scholar 

  14. Salas V, Pastor FJ, Calvo E, Sutton D, García-Hermoso D, Mayayo E, Dromer F, Fothergill A, Alvarez E, Guarro J. Experimental murine model of disseminated infection by Saksenaea vasiformis: successful treatment with posaconazole. Med Mycol. 2012;50(7):710–5. https://doi.org/10.3109/13693786.2012.673137.

    Article  CAS  PubMed  Google Scholar 

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This work was not grant-funded.

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Authors and Affiliations

  1. Singhealth Infectious Diseases Residency, Singapore, Singapore

    Wee Liang En

  2. Department of Infectious Diseases, Changi General Hospital, Singapore, Singapore

    Wee Liang En, Tan Seow Yen & Raymond Fong

  3. Department of Microbiology, Singapore General Hospital, Singapore, Singapore

    Tan Ai Ling & Tan Yen Ee

  4. Department of Laboratory Medicine, Changi General Hospital, Singapore, Singapore

    Tan Sze Hwa

  5. Department of Dermatology, Changi General Hospital, Singapore, Singapore

    Ang Chia Chun

  6. Department of Medicine (Rheumatology Service), Changi General Hospital, Singapore, Singapore

    Santosa Anindita

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  1. Wee Liang En
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  2. Tan Seow Yen
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  3. Tan Ai Ling
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  4. Tan Yen Ee
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  5. Tan Sze Hwa
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  8. Raymond Fong
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Correspondence to Wee Liang En.

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Liang En, W., Seow Yen, T., Ai Ling, T. et al. Disseminated Mucormycosis Due to Saksenaea vasiformis Complex in an Immunocompetent Adult with Sustained Response to Posaconazole Treatment. Mycopathologia 185, 577–581 (2020). https://doi.org/10.1007/s11046-020-00443-y

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  • DOI: https://doi.org/10.1007/s11046-020-00443-y

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