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Changing Concepts and Current Definition of Majocchi’s Granuloma

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Abstract

Dermatophytic granuloma characterized by perifollicular granulomatous inflammation was first described by Domenico Majocchi and was later named after him, Majocchi’s granuloma (MG). Although the initial description was related to a dermatophyte Trichophyton tonsurans, later reports linked MG to non-dermatophytes (Phoma, Aspergillus, Malbranchea), which led to a confusion of disease patterns caused by cutaneous pathogens and general opportunistic microorganisms. Furthermore, several causative agents of MG described in the literature were not confirmed as such. Our review addressed the following aspects: (1) significance of histopathological finding for MG diagnosis, (2) dermatophytes as exclusive agents of MG, (3) spectrum of etiological agents causing different types of invasive dermatophytic infections, and (4) treatment options.

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Authors and Affiliations

  1. Department of Dermatology, Faculty of Medicine, Başkent University Adana Hospital, Adana, Turkey

    Murat Durdu

  2. Division of Mycology, Department of Microbiology, Faculty of Medicine, University of Çukurova, Adana, Turkey

    Hazal Kandemir & Macit Ilkit

  3. Westerdijk Fungal Biodiversity Institute, Utrecht, The Netherlands

    G. Sybren de Hoog

  4. Centre of Expertise in Mycology, Radboud University Medical Centre/Canisius Wilhelmina Hospital, Nijmegen, The Netherlands

    G. Sybren de Hoog

Authors
  1. Murat Durdu
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  2. Hazal Kandemir
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  3. Macit Ilkit
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  4. G. Sybren de Hoog
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Correspondence to Macit Ilkit.

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Durdu, M., Kandemir, H., Ilkit, M. et al. Changing Concepts and Current Definition of Majocchi’s Granuloma. Mycopathologia 185, 187–192 (2020). https://doi.org/10.1007/s11046-019-00358-3

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  • DOI: https://doi.org/10.1007/s11046-019-00358-3

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