Skip to main content
Log in

An automated exudate detection scheme supporting diabetic retinopathy screening using spatial-spectral-statistical feature maps

  • Published:
Multimedia Tools and Applications Aims and scope Submit manuscript

Abstract

An automated Diabetic Retinopathy (DR) introspection scheme for early detection of retinopathy signs is realized in this paper. Presence of exudates in retina is considered as an early sign of DR. Therefore, the proposed methodology aims at detection of exudates by transforming the acquired fundus image into a high-dimensional feature map labelled as Spatial-Spectral-Statistical (SSS) feature map that uniquely represents the individual image pixels using a novel characterization scheme. At the onset, a slightly novel pre-processing scheme is fused into the mechanism to address the non-uniform illumination issues present in images. Later, separate feature characterizers and descriptors pertaining to the diverse domains are engaged for extraction of the different features from the input fundus image. These distinct features are then blended to yield the feature map representing the given image. Then a supervised classifier categorizes these features and finally aids in deciding the presence or absence of exudates for the given input. Extensive investigation and relative comparisons performed on publicly available dataset namely DIARETDB0, DIARETDB1 and MESSIDOR demonstrate a consistent average classification accuracy of 97.99%, an attribute owed to the unique feature aggregation scheme that also, makes the methodology robust under different imaging problems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig.9
Fig. 10
Fig. 11

Similar content being viewed by others

References

  1. Agurto C, Barriga E, Murillo S, Chis MP, Davis H, Russell S, Abrrmoff M, Soliz P (2010) Multiscale AM-FM methods for diabetic retinopathy lesion detection. IEEE Trans Medical Imaging 29(2):502–512

    Article  Google Scholar 

  2. Agurto C, Murray V, Yu H, Wigdahl J, Pattichis M, Nemeth S, Barriga ES (2014) A multiscale optimization approach to detect exudates in the macula. IEEE Journal of Biomedical and health informatics 18(4):1328–1336

    Article  Google Scholar 

  3. Aqeel AF, Ganesan S (2014) Automated algorithm for retinal image exudates and Drusens detection, segmentation, and measurement. IEEE International Conference on Electro/Information Technology (EIT):206–215

  4. Chang C-C, Lin C-J (2011) LIBSVM: A library for support vector machines. ACM Transactions on Intelligent Systems and Technology 2:27:1–27:27 Software available at http://www.csie.ntu.edu.tw/_cjlin/libsvm

    Article  Google Scholar 

  5. DIARETDB0, DIARETDB1 (n.d.) https://www.it.lut.fi/project/imageret/

  6. Fraz MM, Jahangir W, Zahid S, Hamayun MM, Barman SA (2017) Multiscale segmentation of exudates in retinal images using contextual cues and ensemble classification. Biomed. Signal Process Control 35:50–62

    Article  Google Scholar 

  7. Garcia M, Valverde C, Lopez MI, Poza J, Hornero R (2013) Comparison of Logistic Regression and Neural Network Classifiers in the Detection of Hard Exudates in Retinal Images. In: 35th Annual International Conference of the IEEE EMBS Osaka, Japan, 3–7 July

    Google Scholar 

  8. Gonzalez RC, Woods RE (2007) Digital Image Processing. Pearson Education, Inc. ISBN 10:013168728X, pp 122–827

  9. Gulshan V, Peng L, Coram M, Stumpe MC, DerekWu BS, Narayanaswamy A, Venugopalan S, Widner K, Madams T, Cuadros J, Kim R, Raman R, Nelson PC, Mega JL, Webster DR (2016) Development and Validation of a Deep Learning Algorithm for Detection of Diabetic Retinopathy in Retinal Fundus Photographs, Innovations in Health Care Delivery. 316(22):1–9

  10. Harangi B, Hajdu A (2014) Detection of Exudates in Fundus Images Using a Markovian Segmentation Model, Engineering in Medicine and Biology Society (EMBC). In: 2014 36th Annual International Conference of the IEEE Year, pp 130–133

    Google Scholar 

  11. Hsu W, Pallawala PMDS, Mong Li L, Kah-Guan Au E (2001) The role of domain knowledge in the detection of retinal hard exudates. In: Proceedings of the IEEE Computer Society Conference on Computer Vision and Pattern Recognition, vol 2, pp 246–251

    Google Scholar 

  12. Kaur J, Mittal D (2018) A generalized method for the segmentation of exudates from pathological retinal fundus images. Biocybernetics and Biomedical Engineering 38(1):27–53

    Article  Google Scholar 

  13. Khojasteh P, Passos Junior LA, Carvalho T (2019) Exudate detection in fundus images using deeply-learnable features. Comput Biol Med 104:62–69

    Article  Google Scholar 

  14. Kovesi P (1999) Image features from phase congruency. Videre: Journal of Computer Vision Research 1(3):1–26

    Google Scholar 

  15. Kovesi P (2002) Edges are not just steps. In: Proceedings of the Fifth Asian Conference on Computer Vision, Melbourne, vol 8, pp 22–28

    Google Scholar 

  16. MESSIDOR (n.d.) http://www.adcis.net/en/third-party/messidor/

  17. Mo J, Zhang L, Feng Y (2018) Exudate-based diabetic macular edema recognition in retinal images using cascaded deep residual networks. Neurocomputing 290:161–171

    Article  Google Scholar 

  18. Muhammad M, Junhao W, Nasrullah N, Song S, Shaukat H (2020) Exudate detection for diabetic retinopathy using pretrained convolutional neural networks. https://doi.org/10.1155/2020/580187

  19. Niemeijer M, van Ginneken B, Russell SR, Suttorp-Schulten MS, Abràmoff MD (2007) Automated detection and differentiation of drusen, exudates, and cotton-wool spots in digital color fundus photographs for diabetic retinopathy diagnosis. Invest Ophthalmol Vis Sci 48(5):2260–2267

    Article  Google Scholar 

  20. Pereira C, Gonçalves L, Ferreira M (2015) Exudate segmentation in fundus images using an ant colony optimization approach. Inf Sci 296:14–24

    Article  MathSciNet  Google Scholar 

  21. Rocha A, Carvalho T, Jelinek2 HF, Goldenstein S, Wainer J (2012) Points of interest and visual dictionaries for automatic retinal lesion detection. IEEE Reviews in Biomedical Engineering 4

  22. Sanchez CI, Hornero R, Lopez MI, Aboy M, Poza J, Abasolo D (2008) A novel automatic image processing algorithm for detection of hard exudates based on retinal image analysis. Med Eng Phys 30:350–357

    Article  Google Scholar 

  23. Sanchez CI, Garcia M, Mayo A, Lopez MI, Hornero R (2009) Retinal image analysis based on mixture models to detect hard exudates. Medical Image Analysis 13(4):650–658

    Article  Google Scholar 

  24. Sopharak A, Uyyanonvara B, Barman S, Williamson TH (2008) Automatic detection of diabetic retinopathy exudate from non-dilated retinal images using mathematical morphology methods. Computerized Medical Imaging and Graphics 32(8):720–727

    Article  Google Scholar 

  25. van Grinsven MJJP, Chakravartyy A, Sivaswamyy J, Theelen T, van Ginneken B, Sanchez CI (2013) A bag of words approach for discriminating between retinal images containing exudates or drusen. In: IEEE 10th international symposium on biomedical imaging: from nano to macro

    Google Scholar 

  26. Wang J, Bai Y, Xia B (2019) Feasibility of Diagnosing Both Severity and Features of Diabetic Retinopathy in Fundus Photography. IEEE Access 7:102589–102597

  27. Wang J, Bai Y, Xia B (2020) Simultaneous Diagnosis of Severity and Features of Diabetic Retinopathy in Fundus Photography Using Deep Learning. IEEE Transactions on Biomedical Health Informatics

  28. Zaki WMDW, Zulkifley MA, Hussain A, Halim WHWA, Mustafa NBA, Ting LS (2016) Diabetic retinopathy assessment: towards an automated system. Biomed Signal Process Control 24:72–82

    Article  Google Scholar 

  29. Zhang X, Thibault G, Decencire E, Marcotegui B, La B, Danno R, Cazuguel G, Quellec G, Lamard M, Massin P, Chabouis A, Victor Z, Erginay A (2014) Exudate detection in color retinal images for mass screening of diabetic retinopathy. Med Image Anal 18(7):1026–1043

    Article  Google Scholar 

Download references

Availability of data and material

Three publicly available datasets namely DIARETDB0, DIARETDB1 and MESSIDOR are utilized for performance analysis of the presented methodology

Code availability

The code developed towards the realization of the framework discussed in the paper forms a part of the author’s research work and hence unavailable.

Funding

This manuscript is a part of the research work executed by the author towards the Doctoral degree. Hence, no grants / funding were received for this work

Author information

Authors and Affiliations

Authors

Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by Remya K.R. and Giriprasad M.N. The first draft of the manuscript was written by Remya K.R. and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to K. R. Remya.

Ethics declarations

Ethics approval

The data utilized in this research was obtained from publicly available benchmarked datasets

Consent to participate

The authors wish to participate in surveys that align with the areas of the submitted manuscript when the journal conducts the same.

Consent for publication

The authors agree to the norms prescribed by the journal to proceed with the publication process post the peer-review

Conflicts of interest/ competing interests

The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.

Additional information

Publisher’s note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Remya, K.R., Giriprasad, M.N. An automated exudate detection scheme supporting diabetic retinopathy screening using spatial-spectral-statistical feature maps. Multimed Tools Appl 81, 9829–9853 (2022). https://doi.org/10.1007/s11042-022-12354-9

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s11042-022-12354-9

Keywords

Navigation