Abstract
Nowadays, diabetic retinopathy, also called as diabetic eye disease, has become a major cause of vision loss. In modern ophthalmology, an accurate detection and grading of diabetic retinopathy using the color retinal fundus photograph remains a challenging task. This proposed work presents an efficient system to detect exudates that will aid the accurate grading of diabetic retinopathy. For this purpose, a novel two-stage hierarchical classifier is introduced to differentiate the pathological and healthy retinal images. Initially, the green channel of each RGB retinal image is preprocessed and the exudates are detected. Next to analyze and discriminate the normal and lesion-affected images, a set of feature vectors based on size, texture, and intensity are extracted. Then, these features are classified using a two-stage hierarchical classifier. Finally, based on this classification result, an automatic grading system for the detection of diabetic retinopathy is developed and validated on five publicly available databases. The proposed grading system achieves 100% sensitivity, 98.24% specificity, and 0.95 AUC, which is high, compared to other state-of-art methods.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Taylor HR, Keeffe JE (2001) World blindness: a 21st century perspective. Brit J Ophthalmol 85(3):261–266
Ding J, Wong TY (2012) Current epidemiology of diabetic retinopathy and diabetic macular edema. Curr Diabetes Rep 12(4):346–354
Yau JWY et al (2012) Global prevalence and major risk factors of diabetic retinopathy. Diabetes Care 35(3):556–564
Ramasubramanian B, Selvaperumal S An efficient approach for the automatic detection of hemorrhages in color retinal images. IET Image Process
Wild S, Gojka R, Andres G, Richard S, Hilary K (2004) Global prevalence of diabetes. Diabetes Care 27(5):1047–1053
World Health Organization (WHO) (2013) Universal eye health: a global action plan 2014–2019
Ramasubramanian B, Selvaperumal S (2016) A stand-alone MATLAB application for the detection of optic disc and macula. In: IEEE international conference on advanced communication, control and computing technologies (ICACCCT'16), May 2016
Ramasubramanian B, Selvaperumal S (2017) An efficient MATLAB App. for the grading of diabetic retinopathy using color fundus images. Int J Control Theory Appl 10:625–638
Baudoin CE, Lay BJ, Klein JC (1984) Automatic detection of microaneurysms in diabetic fluorescein angiography. Rev D Epidemiol St Publique 32(3–4):254–261
Adal KM, Sidibé D, Ali S, Chaum E, Karnowski TP, Mériaudeau F (2014) Automated detection of microaneurysms using scale-adapted blob analysis and semi-supervised learning. Comput Methods Programs Biomed 114(1):1–10
Roychowdhury S, Koozekanani DD, Parhi KK (2014) DREAM: diabetic retinopathy analysis using machine learning. IEEE Trans Biomed Health Inform 18(5)
Osarch A, Mirmehdi M, Thomas B, Markham R (2006) Classification and localization of diabetic related eye disease. In: Proceedings of the European conference on computer vision, vol 2353, pp 325–329
Zhou W, Wu C, Chen D, Yi Y, Du W Automatic microaneurysm detection using the sparse principal component analysis based unsupervised classification method. https://doi.org/10.1109/ACCESS.2017.2671918
Sopharak A, Dailey MN, Uyyanonvara B, Barman S, Williamson T, Moe YA (2011) Machine learning approach to automatic exudates detection in retinal images from diabetic patients. J Mod Opt 57(2):124–135
Seoud L, Hurtut T, Chelbi J (2016) Red lesion detection using dynamic shape features for diabetic retinopathy screening. IEEE Trans Med Imaging 35(4):1116–1126
Walter T et al (2007) Automatic detection of microaneurysms in color fundus images. Med Image Anal 11(6):555–66
Ramasubramanian B, Mahendran G (2012) An efficient integrated approach for the detection of exudates and diabetic maculopathy in colour fundus images. Adv Comput: Int J 03(5):83–91
Tang L, Niemeijer M, Reinhardt JM (2013) Splat feature classification with application to retinal hemorrhage detection in fundus images. IEEE Trans Med Imaging 32(2):364–375
Agurto C, Murray V, Barriga E (2010) Multiscale AM-FM methods for diabetic retinopathy lesion detection. IEEE Trans Med Imaging 29(2):502–512
Sinthanayothin C et al (2002) Automated detection of diabetic retinopathy on digital fundus images. Diabetic Med AJ Brit Diabetic Assoc 19(2):105–112
Ravishankar S, Jain A, Mittal A (2009) Automated feature extraction for early detection of diabetic retinopathy in fundus images. In: IEEE conference on computer vision and pattern recognition
van Grinsven MJJP, van Ginneken B, Hoyng CB (2016) Fast convolutional neural network training using selective data sampling: application to hemorrhage detection in color fundus images. IEEE Trans Med Imaging 35(5):1273–1284
Roychowdhury S, Koozekanani DD, Parhi KK (2012) Screening fundus images for diabetic retinopathy. In: Proceedings of the conference record of the 46th Asilomar conference on signals, systems and computers, pp 1641–1645
Krizhevsky A, Sutskever I, Hinton GE (2012) Imagenet classification with deep convolutional neural networks. In: Advances in neural information processing systems, pp 1097–1105
Srinivas M, Roy D, Krishna Mohan C (2016) Discriminative feature extraction from X-ray images using deep convolutional neural networks. In: ICASSP, pp 917–921
Mizutani A, Muramatsu C, Hatanaka Y et al Automated microaneurysms detection method based on double ring filter in retinal fundus images. SPIE Med Imaging Comput Aid Diagn 7260:72601N–72601N-8
Lu X et al (2017) Feature extraction and fusion using deep convolutional neural networks for face detection. Hindawi Math Probl Eng
Simonyan K, Zisserman A Very deep convolutional networks for large-scale image recognition. http://arxiv.org/abs/1409.1556
Zeiler M, Fergus R (2014) Visualizing and understanding convolutional networks. In: Proceedings of the European conference on computer vision, pp 818–833
(2011) Methods to evaluate segmentation and indexing techniques in the field of retinal ophthalmology. http://messidor.crihan.fr/download-en.php.
Staal J, Abramoff M, Niemeijer M, Viergever M, van Ginneken B (2004) Ridge based vessel segmentation in color images of the retina. IEEE Trans Med Imaging 23:501–509
Kauppi T, Kalesnykiene V, Kamarainen J-K, Lensu L, Sorri I, Uusitalo H, Klviinen H, Pietil J (2006) Diaretdb0: evaluation database and methodology for diabetic retinopathy algorithms. Tech. Rep., Lappeenranta University of Technology, Finland
Kauppi T, Kalesnykiene V, Kmrinen J-K, Lensu L, Sorr I, Raninen A, Voutilainen R, Uusitalo H, Klviinen H, Pietil J (2007) Diaretdb1 diabetic retinopathy database and evaluation protocol. In: Proceedings of the 11th conference on medical image understanding and analysis (MIUA2007), pp 61–65
Lecun Y, Bottou L, Bengio Y, Haffner P (1998) Gradient-based learning applied to document recognition. Proc IEEE 86(11):2278–2324
Fukushima K (1980) Neocognitron: a self-organizing neural network model for a mechanism of pattern recognition unaffected by shift in position. Biol Cybern 36(4):193–202
Odstrcilik J et al (2013) Retinal vessel segmentation by improved matched filtering: evaluation on a new high-resolution fundus image database. IET Image Process 7(4):373–383
Hoover A, Goldbaum M (2003) Locating the optic nerve in retinal image using the fuzzy convergence of blood vessels. IEEE Trans Med Imaging 22
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2023 The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
About this paper
Cite this paper
Ramasubramanian, B., Hemanand, D., Kavinkumar, K., Muthu Manjula, M. (2023). An Efficient System for Grading Diabetic Retinopathy by Detecting the Location of Lesions. In: Pandit, M., Gaur, M.K., Kumar, S. (eds) Artificial Intelligence and Sustainable Computing. ICSISCET 2022. Algorithms for Intelligent Systems. Springer, Singapore. https://doi.org/10.1007/978-981-99-1431-9_57
Download citation
DOI: https://doi.org/10.1007/978-981-99-1431-9_57
Published:
Publisher Name: Springer, Singapore
Print ISBN: 978-981-99-1430-2
Online ISBN: 978-981-99-1431-9
eBook Packages: Intelligent Technologies and RoboticsIntelligent Technologies and Robotics (R0)