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CircRNAs: novel therapeutic targets in multiple myeloma

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Abstract

Background

Circular RNA (circRNA) is a type of non-coding RNA that has recently attracted the attention of researchers. Multiple myeloma (MM) is a hematological malignancy with a dismal prognosis that indicates a pressing need for better treatment alternatives, particularly in terms of biological indicators. According to recent research findings, the presence of circRNA is also closely related to the incidence and progression of malignant hemopathy. There have been, however, only a few investigations of circRNA in MM.

Material and methods

This review will be on the biological properties and functions of circRNA in MM and a discussion of the clinical utility of circRNA in the diagnosis, prognosis, and treatment of MM.

Conclusions

CircRNA is involved in gene transcription, translation, and epigenetic modification as well as the regulation of cancer cell proliferation, invasion, and metastasis, and hence, promotes or inhibits the occurrence and progression of MM. Therefore, circRNA holds promise as a potential future MM biomarker.

Graphical abstract

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Fig. 1

source of ciRNA by avoiding lariat debranching

Fig. 2

Similar content being viewed by others

Data availability

Data sharing not applicable to this article as no datasets were generated or analyzed during the current study.

Abbreviations

BTZ:

Bortezomib

CDK2:

Cyclin-dependent kinase 2

ceRNA:

Competing endogenous RNA

ciRNA:

Intronic circRNA

CIN:

Chromosomal instability

circRNA:

Circular RNA

ecircRNA:

Exonic circRNA

eicircRNA:

Exonic-intronic circRNA

exo-circRNA:

Exosomal circular RNA

FISH:

Fluorescence in situ hybridization

HD:

Healthy donor

lncRNA:

Long noncoding RNA

MM:

Multiple myeloma

miRNA:

MicroRNA

MRE:

MiRNA response element

mRNA:

Messenger RNA

ncRNA:

Non-coding RNA

OS:

Overall survival

PFS:

Progression-free surviva

PN:

Peripheral neuropathy

RBP:

RNA-binding protein

snRNP:

Small nuclear ribonucleoprotein

TLR4:

Toll-like receptor-4

YAP:

Yes-associated protein

YY1:

Yin Yang 1

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Funding

This work was supported by the National Natural Science Foundation of China 82170198, 81870164, 81372543, and 81170500 to JD.

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  1. Department of Hematology, Myeloma and Lymphoma Center, Shanghai Changzheng Hospital, Naval Medical University, No. 415 Fengyang Road, Huangpu Area, Shanghai, 200003, China

    Xinyi Zhou & Juan Du

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  1. Xinyi Zhou
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  2. Juan Du
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Correspondence to Juan Du.

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Zhou, X., Du, J. CircRNAs: novel therapeutic targets in multiple myeloma. Mol Biol Rep 49, 10667–10676 (2022). https://doi.org/10.1007/s11033-022-07668-8

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