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Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer

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Abstract

Tumor necrosis factor alpha (TNF-α) is a pro-inflammatory cytokine involved in the regulation of the immune system and potentially the progression of cervical neoplastic lesions. In this study, we aimed to explore the possible relationship between polymorphisms of the TNF-α gene and susceptibility to cervical cancer. The relationship between a single nucleotide polymorphism (SNP) in the TNF-α gene (rs1800629) and the risk of cervical cancer was evaluated in a total of 445 subjects with (n = 153), or without (n = 292) cancer. Genotyping was performed using a Taq-Man based real time PCR method. Logistic regression analysis showed that individuals with AG/AA genotypes had an increased risk of cervical cancer compared to those with a GG genotype (OR 3.79, 95% CI 2.4–5.7, < 0.001). Our findings demonstrated that a genetic variant in the TNF-α gene (rs1800629) was associated with increased level and risk of developing cervical cancer, suggesting its potential use as a genetic risk factor for cervical neoplasia.

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Funding

This study was supported by a grant from Mashhad University of Medical Sciences.

Author information

Author notes

  1. Negin Behboodi, Marjaneh Farazestanian, Azam Rastgar-Moghadam, Ehsan Karimi and Majid Rajabian Equally contributed as first authors.

Authors and Affiliations

  1. Department of Biology, Mashhad Branch, Islamic Azad University, Mashhad, Iran

    Negin Behboodi & Ehsan Karimi

  2. Metabolic Syndrome Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Negin Behboodi, Azam Rastgar-Moghadam, Mehrane Mehramiz, Shadi Khorrami & Amir Avan

  3. Department of Obstetrics and Gynecology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Negin Behboodi, Marjaneh Farazestanian & Malihe Hasanzadeh

  4. Department of Biochemistry, Payame-Noor University, Mashhad, Iran

    Majid Rajabian

  5. Department of Biology, Faculty of Science, Payame Noor University, Tehran, Po Box 19395-3697, Iran

    Majid Rajabian

  6. Iranshahr University of Medical Sciences, Iranshahr, Iran

    Farzad Rahmani

  7. Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Farzad Rahmani, Shadi Khorrami & Amir Avan

  8. Department of Pathology, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Amirhosein Jafarian & Noorieh Sharifi-Sistani

  9. Division of Medical Education, Brighton & Sussex Medical School, Falmer, Brighton, BN1 9PH, Sussex, UK

    Gordon A. Ferns

  10. Medical Genetics Research Center, Mashhad University of Medical Sciences, Mashhad, Iran

    Amir Avan

  11. Metabolic Syndrome Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran

    Malihe Hasanzadeh

Authors
  1. Negin Behboodi
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  2. Marjaneh Farazestanian
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  3. Azam Rastgar-Moghadam
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  4. Mehrane Mehramiz
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  5. Ehsan Karimi
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  6. Majid Rajabian
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  7. Farzad Rahmani
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  8. Shadi Khorrami
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  9. Amirhosein Jafarian
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  10. Noorieh Sharifi-Sistani
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  11. Gordon A. Ferns
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  12. Amir Avan
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  13. Malihe Hasanzadeh
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Corresponding authors

Correspondence to Amir Avan or Malihe Hasanzadeh.

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Behboodi, N., Farazestanian, M., Rastgar-Moghadam, A. et al. Association of a variant in the tumor necrosis factor alpha gene with risk of cervical cancer. Mol Biol Rep 48, 1433–1437 (2021). https://doi.org/10.1007/s11033-021-06185-4

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  • DOI: https://doi.org/10.1007/s11033-021-06185-4

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