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Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis

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Abstract

Tumor necrosis factor alpha (TNF-α) is a vital cytokine involved in inflammation, immunity, and cellular organization. The TNFA-308G/A (rs1800629) and -238G/A (rs361525) polymorphisms are two widely investigated variants for their associations with risk of cervical cancer, but the results are conflicting. Here, we performed a meta-analysis to pool the data and evaluate the between-studies heterogeneity. All the case–control studies published from January 1989 to October 2010 on the association between the two polymorphisms of TNFA and cervical cancer risk were identified by searching the electronic literature Medline. The cervical cancer risk associated with the two polymorphisms of TNFA gene was estimated for each study by OR together with its 95% CI, respectively, by using the Review Manager 4.2 software. It was showed that the variant homozygote -308AA was associated with a significantly increased risk of cervical cancer (AA vs. GG: OR = 1.41, 95% CI = 1.03–1.92, P = 0.033; AA vs. GA/GG: OR = 1.39, 95% CI = 1.02–1.90, P = 0.036), and the effect was more evident among Asians (AA vs. GA/GG: OR = 3.67, 95% CI = 1.25–10.81, P = 0.018). We also found that the variant genotypes -238GA/AA was associated with a significantly decreased risk of cervical cancer (GA/AA vs. GG: OR = 0.55, 95% CI = 0.41–0.74, P < 0.001). The results suggested that TNFA-308G/A and -238G/A may contribute to cervical cancer susceptibility.

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Acknowledgments

This work was supported in part by the Program for Changjiang. Scholars and Innovative Research Team in University (IRT0631); Key Project of Nanjing Medical University (07NMUZ011), Natural Science Foundation of Jiangsu Colleges (08KJB330002) and Project for Public Technology Service Center for Reproductive Health in Humans (BM2007709 and BM2008151).

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Authors and Affiliations

  1. Tumor Hospital of Nantong City, Nantong, 226000, China

    Li Liu, Xiaojun Chen & Zengyan Chen

  2. Section of Clinical Epidemiology, Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Cancer Center, 140 Hanzhong Rd, Nanjing, 210029, China

    Li Liu, Xi Yang & Zhibin Hu

  3. Department of Epidemiology and Biostatistics, Nanjing Medical University School of Public Health, Nanjing, 210029, China

    Li Liu & Zhibin Hu

  4. Nanjing Maternity and Child Health Hospital of Nanjing Medical University, Nanjing, 210029, China

    Tinjing Kan & Yan Shen

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  1. Li Liu
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  2. Xi Yang
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  3. Xiaojun Chen
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  5. Yan Shen
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Correspondence to Zhibin Hu.

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Li Liu and Xi Yang contributed equally to this work.

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Liu, L., Yang, X., Chen, X. et al. Association between TNF-α polymorphisms and cervical cancer risk: a meta-analysis. Mol Biol Rep 39, 2683–2688 (2012). https://doi.org/10.1007/s11033-011-1022-9

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  • DOI: https://doi.org/10.1007/s11033-011-1022-9

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