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Current perspectives on the dysregulated microRNAs in gastric cancer

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Abstract

Since gastric cancer (GC) is diagnosed at advanced stages, the survival rate is low in affected people. In this regard, investigating the mechanisms underlying GC development, are so critical. MiRNAs, which are small non coding RNAs, as a post transcriptional repressor, regulate expression of target genes by stimulating breakage or transcription suppression of their targets therefore aberrant expression of miRNAs leading to GC carcinogenesis. In the last decades, there have been various studies approving the pivotal role of miRNAs in various phases of GC development including cancer initiation, proliferation, migration, invasion, metastasis, angiogenesis, apoptosis, and drug resistance. Therefore, the present review aimed at summarizing the dysregulated miRNAs which contribute to various cellular and developmental mechanisms such as, proliferation, apoptosis, invasion, migration, and angiogenesis. Moreover, it provides an overview on novel miRNAs involved in drug resistance and circular miRNAs as cancer biomarkers. Thereafter, it is hoped that the present study will shed more light on diagnostic and prognostic biomarkers of GC, and potential GC treatments based on miRNAs.

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Authors and Affiliations

  1. Department of Animal Biology, Faculty of Natural Sciences, University of Tabriz, Tabriz, Iran

    Shirin Azarbarzin, Reza Safaralizadeh & Mahdi Banan Khojasteh

  2. Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran

    Amir Baghbanzadeh & Behzad Baradaran

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  1. Shirin Azarbarzin
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  2. Reza Safaralizadeh
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  3. Mahdi Banan Khojasteh
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  4. Amir Baghbanzadeh
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  5. Behzad Baradaran
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SA conducted the literature search and did writing. RS and BB conceptualized the ideas and contributed to writing and preparing the final version of the manuscript. AB and MBK prepared the figures and tables and contributed to writing. All authors have read and approved the final manuscript.

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Correspondence to Reza Safaralizadeh or Behzad Baradaran.

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Azarbarzin, S., Safaralizadeh, R., Khojasteh, M.B. et al. Current perspectives on the dysregulated microRNAs in gastric cancer. Mol Biol Rep 47, 7253–7264 (2020). https://doi.org/10.1007/s11033-020-05720-z

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