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The long non-coding RNAs (lncRNA) in the pathogenesis of gastric cancer cells: molecular mechanisms and involvement miRNAs

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Abstract

A complex sequence of occurrences, including host genetic vulnerability, Helicobacter pylori infection, and other environmental variables, culminate in gastric cancer (GC). The development of several genetic and epigenetic changes in oncogenes and tumor suppressor genes causes dysregulation of several signaling pathways, which upsets the cell cycle and the equilibrium between cell division and apoptosis, leading to GC. Developments in computational biology and RNA-seq technology enable quick detection and characterization of long non-coding RNAs (lncRNAs). Recent studies have shown that long non-coding RNAs (lncRNAs) have multiple roles in the development of gastric cancer. These lncRNAs interact with molecules of protein, RNA, DNA, and/or combinations. This review article explores several gastric cancer-associated lncRNAs, such as ADAMTS9-AS2, UCA1, XBP-1, and LINC00152. These various lncRNAs could change GC cell apoptosis, migration, and invasion features in the tumor microenvironment. This review provides an overview of the most recent research on lncRNAs and GC cell apoptosis, migration, invasion, and drug resistance, focusing on studies conducted in cancer cells and healthy cells during differentiation.

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Acknowledgements

This study is supported via funding from Prince Sattam bin Abdulaziz University project number (PSAU/2023/R/1445).

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Authors and Affiliations

  1. Department of Medical Laboratory Techniques, Al-Maarif University College, Al-Anbar, Iraq

    Raed Obaid Saleh

  2. Department of Business Administration, Business School, Al al-Bayt University, Mafraq, Jordan

    Sulieman Ibraheem Shelash Al-Hawary

  3. Department of Medical and Technical Information Technology, Bauman Moscow State Technical University, Moscow, Russia

    Ahmad Hammoud

  4. Department of Mathematics and Natural Sciences, Gulf University for Science and Technology, Mishref Campus, Kuwait City, Kuwait

    Ahmad Hammoud

  5. Department of Medical Laboratory, College of Applied Medical Sciences , Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi Arabia

    Ahmed Hjazi

  6. Center of Desert Studies, University of Anbar, Anbar, Iraq

    Sumaya Ayad Abdulrazzaq

  7. School of Applied and Life Sciences, Divison of Research and Innovation, Uttaranchal University, Dehradun, India

    Pranchal Rajput

  8. Scientific Research Center, Al-Ayen University, Thi-Qar, Iraq

    Taif Alawsi

  9. Department of Laser and Optoelectronics Engineering, University of Technology, Baghdad, Iraq

    Taif Alawsi

  10. Anesthesia Techniques, Al–Nisour University College, Baghdad, Iraq

    Mohammed Jawad Alnajar

  11. College of Technical Engineering, The Islamic University, Najaf, Iraq

    Ahmed Alawadi

  12. College of Technical Engineering, The Islamic University of Al Diwaniyah, Al-Qadisiyyah, Iraq

    Ahmed Alawadi

  13. College of Technical Engineering, The Islamic University of Babylon, Babylon, Iraq

    Ahmed Alawadi

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  1. Raed Obaid Saleh
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Contributions

R.S, S.A and A.H: Conceptualization, Writing - Original Draft. S.A and P.A: Conceptualization, Writing - Original Draft, Resources. A.H: Supervision, Project administration. T.A, M.J and A.A: Conceptualization, Writing - Review and Editing.

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Correspondence to Ahmad Hammoud.

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Saleh, R.O., Al-Hawary, S.I.S., Hammoud, A. et al. The long non-coding RNAs (lncRNA) in the pathogenesis of gastric cancer cells: molecular mechanisms and involvement miRNAs. Mol Biol Rep 51, 615 (2024). https://doi.org/10.1007/s11033-024-09546-x

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