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The influence of BoLA-DRB3 alleles on incidence of clinical mastitis, cystic ovary disease and milk traits in Holstein Friesian cattle

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Abstract

The major histocompatibility complex in cattle (BoLA) is regulated by genes that are closely related to the development of the immunological response to pathogens. The most polymorphic BoLA-DRB3.2 locus was analysed in 209 black-and-white Holstein-Friesian cows in Poland in order to a better explanation of influence of MHC on immunity to diseases in dairy cattle. A total of 23 alleles were identified, among which the *24, *16 and *22 alleles were observed with the highest frequency. These alleles were analysed in terms of their association with the occurrence of mastitis, ovarian cysts, retained placenta and uterine abscesses as well as their contribution to production traits (milk yield, protein and fat percentage in milk). It was determined that the BoLA-DRB3.2 *22 and *16 alleles were associated with a lower risk of clinical mastitis; however, a statistical significance was observed only for the *22 allele. Clinical mastitis was observed at a frequency lower by 8% in cows with one copy of the *22 allele compared to cows with 0 copies of the allele. The presence of the *22 allele in the genotype was also associated with higher milk yield, although this association was not statistically significant.

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Acknowledgements

The authors wish to acknowledge financial support from the Ministry of Science and Higher Education in Poland (DS 3259/2016).

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Authors and Affiliations

  1. Department of Cattle Breeding, Institute of Animal Science, University of Agriculture in Krakow, Krakow, Poland

    Joanna Pokorska, Dominika Kułaj, Magdalena Dusza, Andrzej Ochrem & Joanna Makulska

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  1. Joanna Pokorska
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  2. Dominika Kułaj
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Correspondence to Joanna Pokorska.

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Pokorska, J., Kułaj, D., Dusza, M. et al. The influence of BoLA-DRB3 alleles on incidence of clinical mastitis, cystic ovary disease and milk traits in Holstein Friesian cattle. Mol Biol Rep 45, 917–923 (2018). https://doi.org/10.1007/s11033-018-4238-0

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