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Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population

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Abstract

Esophageal cancer is one of the ten most common cancers in the world and has poor prognosis. Apoptosis is considered a fundamental component in cancer pathogenesis. We conducted a hospital-based case–control study to evaluate the genetic effects of 16 apoptosis associated single nucleotide polymorphisms (SNPs) on esophageal cancer development. A total of 380 esophageal squamous cell carcinoma (ESCC) cases and 380 controls were recruited for this study. Genotypes were determined using a custom-by-design 48-Plex SNPscan™ Kit. The caspase8 (CASP8) rs1035142 G>T polymorphism was associated with increased risk of ESCC by heterozygote comparison, homozygote comparison, a dominant genetic model and a recessive genetic model. However, no significant association was detected between the other 15 SNPs and ESCC risk. Stratified analyses indicated a significantly increased risk of ESCC associated with CASP8 rs1035142 G>T polymorphism was evident among all subgroups. These findings indicated that the functional polymorphism CASP8 rs1035142 G>T might contribute to ESCC susceptibility.

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Abbreviations

CI:

Confidential interval

CASP8 :

Caspase8

LD:

Linkage disequilibrium

OR:

Odds ratio

SNPs:

Single nucleotide polymorphisms

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Acknowledgments

This study was supported in part by National Natural Science Foundation of China (81101889, 81000028), Jiangsu Province Natural Science Foundation (BK2010333, BK2011481) and Social Development Foundation of Zhenjiang (SH2010017).

Conflict of interest

The authors have declared that no competing interests exist.

Author information

Authors and Affiliations

  1. Department of Cardiothoracic Surgery, Affiliated People’s Hospital of Jiangsu University, Zhenjiang, 212002, China

    Jun Yin, Weifeng Tang, Aizhong Shao, Xu Wang, Guowen Ding, Chao Liu, Suocheng Chen & Haiyong Gu

  2. Department of Chemotherapy, Cancer Institute, People’s Hospital Affiliated to Jiangsu University, Zhenjiang, 212002, Jiangsu, China

    Liming Wang

  3. Department of Thoracic & Cardiac Surgery, The First Affiliated Hospital of Nanjing Medical University, Nanjing, 210029, China

    Yijang Chen

Authors
  1. Jun Yin
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  2. Weifeng Tang
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  3. Aizhong Shao
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  4. Liming Wang
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  5. Xu Wang
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  6. Guowen Ding
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  7. Chao Liu
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  8. Yijang Chen
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  9. Suocheng Chen
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  10. Haiyong Gu
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Corresponding authors

Correspondence to Suocheng Chen or Haiyong Gu.

Additional information

Jun Yin and Weifeng Tang contributed equally to this work.

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Yin, J., Tang, W., Shao, A. et al. Caspase8 rs1035142 G>T polymorphism was associated with an increased risk of esophageal cancer in a Chinese population. Mol Biol Rep 41, 2037–2043 (2014). https://doi.org/10.1007/s11033-014-3052-6

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  • DOI: https://doi.org/10.1007/s11033-014-3052-6

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