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Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle

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Abstract

The lipoprotein lipase (LPL) gene can be considered a functional candidate gene that regulates fatty acid composition. In this study, genetic associations between fatty acid composition and exonic single nucleotide polymorphisms (SNPs) in the LPL gene were examined using 612 Korean cattle. We investigated the relationship between unsaturated fatty acids and five novel SNPs (c.322G>A, c.329A>T, c.527T>G, c.988C>T and c.1591G>A), and confirmed that three polymorphic SNPs (c.322G>A, c.329A>T and c.1591G>A) were associated with fatty acid composition. Korean cattle with an AA genotype of c.322G>A, c.329A>T, and GA genotype of c.1591G>A had higher levels of monounsaturated fatty acids and carcass traits (P < 0.05). Our findings confirmed that three novel SNPs we identified in the LPL gene can affect fatty acid composition and carcass traits. Therefore, selection for AA and GA genotypes should be recommended to genetically improve beef quality and flavor.

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Acknowledgments

This work was supported by a grant from the Next-Generation BioGreen21 Program (No. PJ008135032011), Rural Development Administration, Republic of Korea.

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Authors and Affiliations

  1. School of Biotechnology, Yeungnam University, Gyeongsan, Gyeongbuk, 712-749, South Korea

    Dongyep Oh, Boomi La, Younhwa Byun & Jungsou Yeo

  2. Institute of Charmpoom Hanwoo, Gyeongsan, Gyeongbuk, 712-210, South Korea

    Yoonseok Lee

  3. Department of Statistics, Yeungnam University, Gyeongsan-si, Gyeongbuk, 712-749, South Korea

    Jeayoung Lee

  4. Green Cross Research Center, 303 Bojeong-dong, Giheung-gu, Yongin, 446-770, South Korea

    Geunhye Yeo

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  1. Dongyep Oh
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  2. Boomi La
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  3. Yoonseok Lee
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  4. Younhwa Byun
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  5. Jeayoung Lee
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  7. Jungsou Yeo
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Correspondence to Jungsou Yeo.

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Dongyep Oh and Boomi La contributed equally to this study.

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Oh, D., La, B., Lee, Y. et al. Identification of novel single nucleotide polymorphisms (SNPs) of the lipoprotein lipase (LPL) gene associated with fatty acid composition in Korean cattle. Mol Biol Rep 40, 3155–3163 (2013). https://doi.org/10.1007/s11033-012-2389-y

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  • DOI: https://doi.org/10.1007/s11033-012-2389-y

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