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Anti-neutral endopeptidase, natriuretic peptides disarrangement, and proteinuria onset in membranous nephropathy

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Abstract

Neutral endopeptidase (NEP) is the first podocytic antigen responsible for human membranous nephropathy (MN). Besides the prevailing pathogenetic mechanism of immune complex, NEP is also involved in the metabolism of natriuretic peptides (NP). The identification of anti-NEP antibodies in human MN suggests that the decreased circulating NEP may down-regulate the NP catabolism. In this context, we hypothesize that NP disarrangement secondary to anti-NEP antibodies may account, in part, for the onset of proteinuria in MN. Whereas the pathways for the onset of proteinuria caused by elevated NP level are still obscure. The data presented in this review focus on those which support this hypothesis with regards to evidence from the glomerular haemodynamic changes, endothelial permeability, glomerular basement membrane disruption, and podocyte detachment.

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Acknowledgments

This study was supported by the National Natural Science Foundation of China (No. 81000306) and the Post-Doctoral Foundation of Anhui Medical University (No. 2009KJ02).

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Authors and Affiliations

  1. Department of Pediatrics, The First Affiliated Hospital of Anhui Medical University, No. 218 Ji-Xi Road, Hefei, 230022, People’s Republic of China

    Peng Hu, Bo Hu & Ling Lu

  2. Department of Urology, Anhui Provincial Hospital, Anhui Medical University, No. 17 Lu-Jiang Road, Hefei, 230001, People’s Republic of China

    Qiang Xuan

  3. Department of Pediatrics, The First Affiliated Hospital of Guangxi Medical University, No. 6 Shuang-Yong Road, Nanning, 530021, People’s Republic of China

    Yuan Han Qin

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  1. Peng Hu
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Correspondence to Peng Hu.

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Hu, P., Xuan, Q., Hu, B. et al. Anti-neutral endopeptidase, natriuretic peptides disarrangement, and proteinuria onset in membranous nephropathy. Mol Biol Rep 40, 2963–2967 (2013). https://doi.org/10.1007/s11033-012-2367-4

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  • DOI: https://doi.org/10.1007/s11033-012-2367-4

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