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Novel single nucleotide polymorphisms of bovine SREBP1 gene is association with fatty acid composition and marbling score in commercial Korean cattle (Hanwoo)

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Abstract

The sterol regulatory element binding factor 1 (SREBP1) gene plays an important role in the biosynthesis of fatty acids. The aim of this study was to investigate the association between SNPs within SREBP1 gene and fatty acid composition of muscle fat and marbling score in a commercial population of Korean cattle. Among 10 SNPs in dbSNP of bovine SREBP1 gene, we identified 7 polymorphic SNPs and 84-bp ins/del variation (SREBP1-INT5 SNP) in commercial Korean cattle (n = 513). The SREBP1-9 SNP showed a significant effect on marbling score, monounsaturated fatty acids and C18:1n-9 in the muscle fat of commercial Korean cattle. However, SREBP1-INT5 SNP showed no effect on any fatty acid composition. Therefore, two polymorphisms in SREBP1 may improve flavored beef and meat quality in commercial Korean cattle.

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Acknowledgments

This work was supported by a grant from Next-Generation BioGreen 21 Program, Rural Development Administration, Republic of Korea (Grant No. PJ008135).

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Authors and Affiliations

  1. Charmpoom Hanwoo Research Institution, Charmpoom Hanwoo Co., Ltd., Chilgok-gun, Gyeongsangbuk-do, 718-913, South Korea

    Yoonseok Lee

  2. School of Biotechnology, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 712-749, South Korea

    Dongyep Oh, Boomi La & Jungsou Yeo

  3. Department of Statistics, Yeungnam University, Gyeongsan-si, Gyeongsangbuk-do, 712-749, South Korea

    Jeayoung Lee

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  1. Yoonseok Lee
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  2. Dongyep Oh
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  5. Jungsou Yeo
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Correspondence to Jungsou Yeo.

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D. Oh authors contributed equally to this study

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Lee, Y., Oh, D., Lee, J. et al. Novel single nucleotide polymorphisms of bovine SREBP1 gene is association with fatty acid composition and marbling score in commercial Korean cattle (Hanwoo). Mol Biol Rep 40, 247–254 (2013). https://doi.org/10.1007/s11033-012-2055-4

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  • DOI: https://doi.org/10.1007/s11033-012-2055-4

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